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Poly(Vinyl Alcohol)-Hydrogel Microparticles with Soft Barrier Shell for the Encapsulation of Micrococcus luteus

Titelangaben

Mafi, Mahsa ; Kushmaro, Ariel ; Greenblatt, Charles ; Agarwal, Seema ; Greiner, Andreas:
Poly(Vinyl Alcohol)-Hydrogel Microparticles with Soft Barrier Shell for the Encapsulation of Micrococcus luteus.
In: Macromolecular Bioscience. Bd. 21 (2021) Heft 5 . - 2000419.
ISSN 1616-5195
DOI: https://doi.org/10.1002/mabi.202000419

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Link zum Volltext (externe URL): Volltext

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Projektfinanzierung: Deutsche Forschungsgemeinschaft

Abstract

The encapsulation of bacteria in polymers results in hybrid materials that are essential for the long-term biological activity of bacteria and formulations in practical applications. Here, the problem of bacterial escape and the exchange of metabolism products from hydrogel microparticles within an aqueous environment are addressed. Bacteria are encapsulated in chemically cross-linked poly(vinyl alcohol) (PVA) hydrogel-microparticles followed by their encapsulation in a pH-responsive and soft antibacterial shell of poly(N,N-diethylamino ethyl methacrylate) (PDEAEMA). This polymer shell acts selectively with regards to the mass transport in and out of the microparticle core and is affected by environmental parameters, such as pH and antibacterial effect. The pH-responsive PDEAEMA shell forms an open porous structure that accelerates nutrient transfer into the PVA core containing living Micrococcus luteus (M. luteus). Results show that the antibacterial effect of PDEAEMA retards the escape of bacteria up to 35 days when the shell is open. Additionally, the permeation of a small molecule into the gel, for example, methylene blue dye through the core/open-shell structure, certifies a flexible barrier for mass transport, which is required in the long term for the biological activity of encapsulated M. luteus.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Keywords: antibacterial polymers; core/shell polymer microparticles; encapsulation;
Micrococcus luteus
Institutionen der Universität: Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie II
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie II > Lehrstuhl Makromolekulare Chemie II - Univ.-Prof. Dr. Andreas Greiner
Profilfelder > Advanced Fields > Polymer- und Kolloidforschung
Fakultäten
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie
Profilfelder
Profilfelder > Advanced Fields
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
Eingestellt am: 30 Mär 2021 07:06
Letzte Änderung: 10 Okt 2023 10:30
URI: https://eref.uni-bayreuth.de/id/eprint/64453