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Blood Glucose Responses during Cardiopulmonary Incremental Exercise Testing in Type 1 Diabetes : A Pooled Analysis

Title data

McCarthy, Olivia ; Pitt, Jason ; Wellman, Ben ; Eckstein, Max L. ; Moser, Othmar ; Bain, Stephen C. ; Bracken, Richard M.:
Blood Glucose Responses during Cardiopulmonary Incremental Exercise Testing in Type 1 Diabetes : A Pooled Analysis.
In: Medicine & Science in Sports & Exercise. Vol. 53 (2021) Issue 6 . - pp. 1142-1150.
ISSN 1530-0315
DOI: https://doi.org/10.1249/MSS.0000000000002584

Abstract in another language

Purpose: To determine the glycemic responses to cardiopulmonary exercise testing (CPET) in individuals with type 1 diabetes (T1D) and to explore the influence of starting blood glucose (BG) concentrations on subsequent CPET outcomes. Methods: This study was a retrospective, secondary analysis of pooled data from three randomised cross-over trials using identical CPET protocols. During cycling, cardiopulmonary variables were measured continuously, with BG and lactate values obtained minutely via capillary earlobe sampling. Anaerobic threshold (AT) was determined using ventilatory parameters. Participants were split into (i) euglycemic ([Eu] >3.9 to ≤10.0 mmol.L, n=26) and (ii) hyperglycemic ([Hyper] >10.0 mmol.L, n=10) groups based on pre-exercise BG concentrations. Data were assessed via general linear modelling techniques and regression analyses. P values of ≤0.05 were accepted as significant. Results: Data from thirty-six individuals with T1D (HbA1c; 7.3±1.1% [56.0±11.5 mmol.mol]) were included. BG remained equivalent to pre-exercise concentrations throughout CPET, with an overall change in BG of -0.32±1.43 mmol.L. Hyper had higher HR at peak (+10±2 bpm, p=0.04) and during recovery (+9±2 bpm, p=0.038) as well as lower O2 pulse during the cool down period (-1.6±0.04 mL.beat, p=0.021). BG responses were comparable between glycemic groups. Higher pre-exercise BG led to greater lactate formation during exercise. HbA1c was inversely related to time to exhaustion (r=-0.388, p=0.04) as well as peak power output (r=-0.355, p=0.006) and O2 pulse (r=-0.308, p=0.015). Conclusion: This study demonstrated 1) stable BG responses to CPET in patients with T1D 2) though pre-exercise hyperglycemia did not influence subsequent glycemic dynamics, it did potentiate alterations in various cardiac and metabolic responses to CPET 3) HbA1c was a significant factor in the determination of peak performance outcomes during CPET.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Cultural Studies > Department of Sport Science > Chair Exercise Physiology > Chair Exercise Physiology - Univ.-Prof. Dr. Othmar Moser
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences > 610 Medicine and health
Date Deposited: 25 May 2021 07:07
Last Modified: 25 May 2021 07:07
URI: https://eref.uni-bayreuth.de/id/eprint/65129