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Identifying heterogeneous diffusion states in the cytoplasm by a hidden Markov model

Titelangaben

Janczura, Joanna ; Balcerek, Michał ; Burnecki, Krzysztof ; Sabri, Adal ; Weiss, Matthias ; Krapf, Diego:
Identifying heterogeneous diffusion states in the cytoplasm by a hidden Markov model.
In: New Journal of Physics. Bd. 23 (2021) Heft 5 . - 053018.
ISSN 1367-2630
DOI: https://doi.org/10.1088/1367-2630/abf204

Abstract

Diffusion of nanoparticles in the cytoplasm of live cells has frequently been reported to exhibit an anomalous and even heterogeneous character, i.e. particles seem to switch gears during their journey. Here we show by means of a hidden Markov model that individual trajectories of quantum dots in the cytoplasm of living cultured cells feature a dichotomous switching between two distinct mobility states with an overall subdiffusive mode of motion of the fractional Brownian motion (FBM) type. Using the extracted features of experimental trajectories as input for simulations of different variants of a two-state FBM model, we show that the trajectory-intrinsic and the ensemble-wise heterogeneity in the experimental data is mostly due to variations in the (local) transport coefficients, with only minor contributions due to locally varying anomaly exponents. Altogether, our approach shows that diffusion heterogeneities can be faithfully extracted and quantified from fairly short trajectories obtained by single-particle tracking in highly complex media.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Institutionen der Universität: Fakultäten
Fakultäten > Fakultät für Mathematik, Physik und Informatik
Fakultäten > Fakultät für Mathematik, Physik und Informatik > Physikalisches Institut
Fakultäten > Fakultät für Mathematik, Physik und Informatik > Physikalisches Institut > Lehrstuhl Experimentalphysik I - Physik lebender Materie
Fakultäten > Fakultät für Mathematik, Physik und Informatik > Physikalisches Institut > Lehrstuhl Experimentalphysik I - Physik lebender Materie > Lehrstuhl Experimentalphysik I - Physik lebender Materie - Univ.-Prof. Dr. Matthias Weiss
Profilfelder > Advanced Fields > Nichtlineare Dynamik
Profilfelder
Profilfelder > Advanced Fields
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 530 Physik
500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
Eingestellt am: 17 Mai 2021 09:37
Letzte Änderung: 13 Dec 2022 08:06
URI: https://eref.uni-bayreuth.de/id/eprint/65200