Titlebar

Export bibliographic data
Literature by the same author
plus on the publication server
plus at Google Scholar

 

Identifying heterogeneous diffusion states in the cytoplasm by a hidden Markov model

Title data

Janczura, Joanna ; Balcerek, Michał ; Burnecki, Krzysztof ; Sabri, Adal ; Weiss, Matthias ; Krapf, Diego:
Identifying heterogeneous diffusion states in the cytoplasm by a hidden Markov model.
In: New Journal of Physics. Vol. 23 (13 May 2021) . - 053018.
ISSN 1367-2630
DOI: https://doi.org/10.1088/1367-2630/abf204

Abstract in another language

Diffusion of nanoparticles in the cytoplasm of live cells has frequently been reported to exhibit an anomalous and even heterogeneous character, i.e. particles seem to switch gears during their journey. Here we show by means of a hidden Markov model that individual trajectories of quantum dots in the cytoplasm of living cultured cells feature a dichotomous switching between two distinct mobility states with an overall subdiffusive mode of motion of the fractional Brownian motion (FBM) type. Using the extracted features of experimental trajectories as input for simulations of different variants of a two-state FBM model, we show that the trajectory-intrinsic and the ensemble-wise heterogeneity in the experimental data is mostly due to variations in the (local) transport coefficients, with only minor contributions due to locally varying anomaly exponents. Altogether, our approach shows that diffusion heterogeneities can be faithfully extracted and quantified from fairly short trajectories obtained by single-particle tracking in highly complex media.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties
Faculties > Faculty of Mathematics, Physics und Computer Science
Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics
Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Chair Experimental Physics I - Physics of Living Matter
Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Chair Experimental Physics I - Physics of Living Matter > Chair Experimental Physics I - Physics of Living Matter - Univ.-Prof. Dr. Matthias Weiss
Profile Fields > Advanced Fields > Nonlinear Dynamics
Profile Fields
Profile Fields > Advanced Fields
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 530 Physics
500 Science > 570 Life sciences, biology
Date Deposited: 17 May 2021 09:37
Last Modified: 15 Jul 2021 09:27
URI: https://eref.uni-bayreuth.de/id/eprint/65200