Literatur vom gleichen Autor/der gleichen Autor*in
plus bei Google Scholar

Bibliografische Daten exportieren
 

Soft Elastic Fibrous Scaffolds for Muscle Tissue Engineering by Touch Spinning

Titelangaben

Uribe Gómez, Juan Manuel ; Posada Murcia, Andrés ; Shukla, Amit ; Alkhamis, Hanin ; Salehi, Sahar ; Ionov, Leonid:
Soft Elastic Fibrous Scaffolds for Muscle Tissue Engineering by Touch Spinning.
In: ACS Applied Bio Materials. Bd. 4 (2021) Heft 7 . - S. 5585-5597.
ISSN 2576-6422
DOI: https://doi.org/10.1021/acsabm.1c00403

Angaben zu Projekten

Projektfinanzierung: Deutsche Forschungsgemeinschaft

Abstract

This paper reports an approach for the fabrication of highly aligned soft elastic fibrous scaffolds using touch spinning of thermoplastic polycaprolactone–polyurethane elastomers and demonstrates their potential for the engineering of muscle tissue. A family of polyester–polyurethane soft copolymers based on polycaprolactone with different molecular weights and three different chain extenders such as 1,4-butanediol and polyethylene glycols with different molecular weight was synthesized. By varying the molar ratio and molecular weights between the segments of the copolymer, different physicochemical and mechanical properties were obtained. The polymers possess elastic modulus in the range of a few megapascals and good reversibility of deformation after stretching. The combination of the selected materials and fabrication methods allows several essential advantages such as biocompatibility, biodegradability, suitable mechanical properties (elasticity and softness of the fibers), high recovery ratio, and high resilience mimicking properties of the extracellular matrix of muscle tissue. Myoblasts demonstrate high viability in contact with aligned fibrous scaffolds, where they align along the fibers, allowing efficient cell patterning on top of the structures. Altogether, the importance of this approach is the fabrication of highly oriented fiber constructs that can support the proliferation and alignment of muscle cells for muscle tissue engineering applications.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Keywords: Touch-spinning; biofabrication; skeletal muscle; polyurethane copolymers; microfibers
Institutionen der Universität: Fakultäten > Fakultät für Ingenieurwissenschaften > Professur Biofabrikation
Fakultäten > Fakultät für Ingenieurwissenschaften > Professur Biofabrikation > Professur Biofabrikation - Univ.-Prof. Dr. Leonid Ionov
Fakultäten
Fakultäten > Fakultät für Ingenieurwissenschaften
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften
500 Naturwissenschaften und Mathematik > 540 Chemie
500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften
URN: urn:nbn:de:bvb:703-epub-5725-3
Eingestellt am: 20 Aug 2021 10:24
Letzte Änderung: 23 Dec 2021 11:07
URI: https://eref.uni-bayreuth.de/id/eprint/66823