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Correlating rheology and printing performance of fiber-reinforced bioinks to assess predictive modelling for biofabrication

Titelangaben

Sonnleitner, David ; Schrüfer, Stefan ; Berglund, Linn ; Schubert, Dirk W. ; Lang, Gregor:
Correlating rheology and printing performance of fiber-reinforced bioinks to assess predictive modelling for biofabrication.
In: Journal of Materials Research. Bd. 36 (2021) Heft 19 . - S. 3821-3832.
ISSN 2044-5326
DOI: https://doi.org/10.1557/s43578-021-00276-5

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Link zum Volltext (externe URL): Volltext

Angaben zu Projekten

Projekttitel:
Offizieller Projekttitel
Projekt-ID
SFB/TRR 225 "Biofabrication"
A07

Projektfinanzierung: Deutsche Forschungsgemeinschaft

Abstract

A crucial property for the evaluation of bioinks, besides biocompatibility, is printability, which is determined by resolution and shape fidelity. Recently, fiber reinforcement was used to overcome rheological limitations and introduce biomimetic structuring. This study provides a systematic approach to evaluate the printability of fiber reinforced hydrogels. Alginate and Pluronic hydrogels were blended with cellulose nanofibers (CeNF) and polycaprolactone (PCL) microfibers. SEM imaging revealed fiber-induced structural changes. Oscillatory rheological experiments showed that the addition of fiber fragments significantly altered the complex viscosity. A customized setup was utilized to determine strut spreading behavior in a real extrusion printing process. Strikingly, the data displayed excellent correlation with viscoelastic model-based predictions. CeNF increased the shape fidelity of both hydrogels, while PCL microfibers increased the viscosity but resulted in a time dependent loss of structural integrity in Pluronic. The results emphasize the need to complement shear-rheological analysis of bioinks by print-related customized analytical tools.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Keywords: 3D printing; Composite; Extrusion; Fiber; Modeling; Viscoelasticity
Institutionen der Universität: Fakultäten > Fakultät für Ingenieurwissenschaften > Juniorprofessur Biopolymerverarbeitung > Juniorprofessur Biopolymerverarbeitung - Juniorprof. Dr.-Ing. Gregor Lang
Fakultäten
Fakultäten > Fakultät für Ingenieurwissenschaften
Fakultäten > Fakultät für Ingenieurwissenschaften > Juniorprofessur Biopolymerverarbeitung
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften
Eingestellt am: 25 Sep 2021 21:00
Letzte Änderung: 07 Jul 2022 13:32
URI: https://eref.uni-bayreuth.de/id/eprint/67116