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Correlating rheology and printing performance of fiber-reinforced bioinks to assess predictive modelling for biofabrication

Title data

Sonnleitner, David ; Schrüfer, Stefan ; Berglund, Linn ; Schubert, Dirk W. ; Lang, Gregor:
Correlating rheology and printing performance of fiber-reinforced bioinks to assess predictive modelling for biofabrication.
In: Journal of Materials Research. (July 2021) .
ISSN 2044-5326
DOI: https://doi.org/10.1557/s43578-021-00276-5

Official URL: Volltext

Project information

Project title:
Project's official titleProject's id
SFB/TRR 225 "Biofabrication"A07

Project financing: Deutsche Forschungsgemeinschaft

Abstract in another language

A crucial property for the evaluation of bioinks, besides biocompatibility, is printability, which is determined by resolution and shape fidelity. Recently, fiber reinforcement was used to overcome rheological limitations and introduce biomimetic structuring. This study provides a systematic approach to evaluate the printability of fiber reinforced hydrogels. Alginate and Pluronic hydrogels were blended with cellulose nanofibers (CeNF) and polycaprolactone (PCL) microfibers. SEM imaging revealed fiber-induced structural changes. Oscillatory rheological experiments showed that the addition of fiber fragments significantly altered the complex viscosity. A customized setup was utilized to determine strut spreading behavior in a real extrusion printing process. Strikingly, the data displayed excellent correlation with viscoelastic model-based predictions. CeNF increased the shape fidelity of both hydrogels, while PCL microfibers increased the viscosity but resulted in a time dependent loss of structural integrity in Pluronic. The results emphasize the need to complement shear-rheological analysis of bioinks by print-related customized analytical tools.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: 3D printing; Composite; Extrusion; Fiber; Modeling; Viscoelasticity
Institutions of the University: Faculties > Faculty of Engineering Science > Junior Professor Biopolymer Processing > Junior Professor Biopolymer Processing - Juniorprof. Dr.-Ing. Gregor Lang
Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Junior Professor Biopolymer Processing
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 25 Sep 2021 21:00
Last Modified: 27 Sep 2021 07:38
URI: https://eref.uni-bayreuth.de/id/eprint/67116