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Acute Metabolic Responses to Glucose and Fructose Supplementation in Healthy Individuals : A Double-Blind Randomized Crossover Placebo-Controlled Trial

Title data

Eckstein, Max L. ; Brockfeld, Antonia ; Haupt, Sandra ; Schierbauer, Janis ; Zimmer, Rebecca T. ; Wachsmuth, Nadine ; Zunner, Beate ; Zimmermann, Paul ; Obermayer-Pietsch, Barbara ; Moser, Othmar:
Acute Metabolic Responses to Glucose and Fructose Supplementation in Healthy Individuals : A Double-Blind Randomized Crossover Placebo-Controlled Trial.
In: Nutrients. Vol. 13 (2021) Issue 11 . - No. 4095.
ISSN 2072-6643
DOI: https://doi.org/10.3390/nu13114095

Official URL: Volltext

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Abstract in another language

The aim of this study was to investigate the impact of glucose (Glu), fructose (Fru), glucose and fructose (GluFru) and sucralose on blood glucose response in healthy individuals. Fifteen healthy individuals (five females, age of 25.4 ± 2.5 years, BMI of 23.7 ± 1.7 kg/m2 with a body mass (BM) of 76.3 ± 12.3 kg) participated in this double-blind randomized crossover placebo-controlled trial. Participants received a mixture of 300 mL of water with 1 g/kg BM of Glu, 1 g/kg BM of Fru, 0.5 g/kg BM of GluFru (each), and 0.2 g sucralose as a placebo. Peak BG values Glu were reached after 40 ± 13 min (peak BG: 141 ± 20 mg/dL), for Fru after 36 ± 22 min (peak BG: 98 ± 7 mg/dL), for GluFru after 29 ± 8 min (BG 128 ± 18 mg/dL), and sucralose after 34 ± 27 min (peak BG: 83 ± 5 mg/dL). Significant differences regarding the time until peak BG were found only between Glu and GluFru supplementation (p = 0.02). Peak blood glucose levels were significantly lower following the ingestion of Fru compared to the supplementation of Glu and GluFru (p < 0.0001) while Glu and GluFru supplementation showed no difference in peak values (p = 0.23). All conditions led to a significantly higher peak BG value compared to sucralose (p < 0.0001). Blood lactate increased in Glu (p = 0.002), Fru and GluFru (both p < 0.0001), whereas sucralose did not increase compared to the baseline (p = 0.051). Insulin levels were significantly higher in all conditions at peak compared to sucralose (p < 0.0001). The findings of this study prove the feasibility of combined carbohydrate supplementations for many applications in diabetic or healthy exercise cohorts.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: glucose; metabolism; fructose; sucralose; healthy individuals; insulin; substrate oxidation
Institutions of the University: Faculties > Faculty of Cultural Studies > Department of Sport Science > Chair Exercise Physiology
Faculties > Faculty of Cultural Studies > Department of Sport Science > Chair Exercise Physiology > Chair Exercise Physiology - Univ.-Prof. Dr. Othmar Moser
Faculties
Faculties > Faculty of Cultural Studies
Faculties > Faculty of Cultural Studies > Department of Sport Science
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences > 610 Medicine and health
Date Deposited: 18 Jan 2022 10:11
Last Modified: 01 Aug 2022 08:44
URI: https://eref.uni-bayreuth.de/id/eprint/68405