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Colloidally Stable and Surfactant-Free Protein-Coated Gold Nanorods in Biological Media

Title data

Tebbe, Moritz ; Kuttner, Christian ; Männel, Max ; Fery, Andreas ; Chanana, Munish:
Colloidally Stable and Surfactant-Free Protein-Coated Gold Nanorods in Biological Media.
In: ACS Applied Materials & Interfaces. Vol. 7 (2015) Issue 10 . - pp. 5984-5991.
ISSN 1944-8252
DOI: https://doi.org/10.1021/acsami.5b00335

Official URL: Volltext

Abstract in another language

In this work, we investigate the ligand exchange of cetyltrimethylammonium bromide (CTAB) with bovine serum albumine (BSA) for gold nanorods. We demonstrate by surface-enhanced Raman scattering (SERS) measurements, that CTAB, which is used as a shape-directing agent in the particle synthesis, is completely removed from solution and particle surface. Thus the protein-coated nanorods are suitable for bioapplications, where cationic surfactants have to be avoided. At the same time, the colloidal stability of the system is significantly increased, as evidenced by spectroscopic investigation of the particles longitudinal surface plasmon resonance, which is sensitive towards aggregation. Particles are stable at very high concentrations (cAu 20 mg/mL) in biological media such as phosphate buffer saline (PBS) or Dulbecco’s Modified Eagle’s Medium (DMEM) and over a large pH-range (2-12). Particles can even be freeze-dried (lyophilized) and redispersed. The protocol was applied to gold nanoparticles with a large range of aspect ratios and sizes with main absorption frequencies covering the visible and the near infrared (NIR) spectral range from 600 to 1100 nm. Thus, these colloidally stable and surfactant-free protein-coated nanoparticles are of great interest for various plasmonic and biomedical applications.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Physical Chemistry II - Univ.-Prof. Dr. Andreas Fery
Profile Fields > Advanced Fields > Polymer and Colloid Science
Research Institutions > EU Research Projects > METAMECH - Template Assisted Assembly of Meta-Materials Using Mechanical Instabilities
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Physical Chemistry II
Profile Fields
Profile Fields > Advanced Fields
Research Institutions
Research Institutions > EU Research Projects
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 530 Physics
500 Science > 540 Chemistry
Date Deposited: 19 Mar 2015 09:15
Last Modified: 19 Mar 2015 09:15
URI: https://eref.uni-bayreuth.de/id/eprint/8401