Titelangaben
Arsenie, Laura Vasilica ; Semsarilar, Mona ; Brendel, Johannes C. ; Lacroix-Desmazes, Patrick ; Ladmiral, Vincent ; Catrouillet, Sylvain:
Supramolecular co-assembly of water-soluble nucleobase-containing copolymers : bioinspired synthetic platforms towards new biomimetic materials.
In: Polymer Chemistry.
Bd. 13
(2022)
Heft 39
.
- S. 5604-5615.
ISSN 1759-9954
DOI: https://doi.org/10.1039/D2PY00872F
Abstract
This study presents the development of co-assembled copolymer architectures at physiological pH (pH 7.4) formed via H-bonds between complementary nucleobase-containing copolymers. Well-defined hydrophilic copolymers were synthesised by RAFT polymerisation: statistical uracil- and thiomorpholine oxide-containing copolymers P(UrMAn-stat-THOXMAm) as well as diblock copolymers PEG112-b-P(AdMAn-stat-THOXMAm) composed of a PEG block and a second block of a copolymer of adenine- and thiomorpholine oxide-derived methacrylates. Binary mixtures of the resulting copolymers formed co-assembled nanoobjects in aqueous solution as a result of the H-bonds established between nucleobases. The influences of the polymer architecture (degree of polymerisation, co-monomer composition, length of the nucleobase-containing block), the ratio between complementary nucleobases, and the impact of H-bond competitors on the self-assembly properties were investigated. Light scattering techniques (SLS, DLS) and transmission electron microscopy (TEM) were used to characterise the co-assembled objects. This study demonstrates that the size of the resulting co-assemblies was mainly governed by the type and content of nucleobases, and by the length of the nucleobase block. Moreover, the in vitro evaluation of the nucleobase-containing polymers revealed that they were non-cytotoxic and hemocompatible. This study increases the understanding of nucleobase pairing in artificial copolymer architectures which are potential platforms for further use in biosciences.
Weitere Angaben
Publikationsform: | Artikel in einer Zeitschrift |
---|---|
Begutachteter Beitrag: | Ja |
Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie I Fakultäten Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie I > Lehrstuhl Makromolekulare Chemie I - Univ.-Prof. Dr. Johannes C. Brendel |
Titel an der UBT entstanden: | Nein |
Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
Eingestellt am: | 21 Feb 2024 08:02 |
Letzte Änderung: | 02 Mai 2024 07:39 |
URI: | https://eref.uni-bayreuth.de/id/eprint/88565 |