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Supramolecular co-assembly of water-soluble nucleobase-containing copolymers : bioinspired synthetic platforms towards new biomimetic materials

Titelangaben

Arsenie, Laura Vasilica ; Semsarilar, Mona ; Brendel, Johannes C. ; Lacroix-Desmazes, Patrick ; Ladmiral, Vincent ; Catrouillet, Sylvain:
Supramolecular co-assembly of water-soluble nucleobase-containing copolymers : bioinspired synthetic platforms towards new biomimetic materials.
In: Polymer Chemistry. Bd. 13 (2022) Heft 39 . - S. 5604-5615.
ISSN 1759-9954
DOI: https://doi.org/10.1039/D2PY00872F

Abstract

This study presents the development of co-assembled copolymer architectures at physiological pH (pH 7.4) formed via H-bonds between complementary nucleobase-containing copolymers. Well-defined hydrophilic copolymers were synthesised by RAFT polymerisation: statistical uracil- and thiomorpholine oxide-containing copolymers P(UrMAn-stat-THOXMAm) as well as diblock copolymers PEG112-b-P(AdMAn-stat-THOXMAm) composed of a PEG block and a second block of a copolymer of adenine- and thiomorpholine oxide-derived methacrylates. Binary mixtures of the resulting copolymers formed co-assembled nanoobjects in aqueous solution as a result of the H-bonds established between nucleobases. The influences of the polymer architecture (degree of polymerisation, co-monomer composition, length of the nucleobase-containing block), the ratio between complementary nucleobases, and the impact of H-bond competitors on the self-assembly properties were investigated. Light scattering techniques (SLS, DLS) and transmission electron microscopy (TEM) were used to characterise the co-assembled objects. This study demonstrates that the size of the resulting co-assemblies was mainly governed by the type and content of nucleobases, and by the length of the nucleobase block. Moreover, the in vitro evaluation of the nucleobase-containing polymers revealed that they were non-cytotoxic and hemocompatible. This study increases the understanding of nucleobase pairing in artificial copolymer architectures which are potential platforms for further use in biosciences.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Institutionen der Universität: Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie I
Fakultäten
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie I > Lehrstuhl Makromolekulare Chemie I - Univ.-Prof. Dr. Johannes C. Brendel
Titel an der UBT entstanden: Nein
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
Eingestellt am: 21 Feb 2024 08:02
Letzte Änderung: 02 Mai 2024 07:39
URI: https://eref.uni-bayreuth.de/id/eprint/88565