Burden of cancer attributable to sedentary behaviour in Germany : an epidemiological analysis of survey data

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Schaber, Katharina ; Leitzmann, Michael ; Pukrop, Tobias ; Quentin, Wilm ; Stein, Michael J. ; Jochem, Carmen:
Burden of cancer attributable to sedentary behaviour in Germany : an epidemiological analysis of survey data.
In: BMJ Open. Bd. 15 (14 Januar 2025) Heft 1 .
ISSN 2044-6055
DOI: https://doi.org/10.1136/bmjopen-2024-094304

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Abstract

Objectives
Sedentary behaviour (SB) is associated with
increased risks of breast, colorectal, endometrial, ovarian
and rectal cancers. However, the number of cancer cases
attributable to SB in Germany and the associated costs are
unknown.

Setting
Numbers and proportions (population-attributable
fractions, PAF) of new cancer cases attributable to SB with
published risk estimates for Germany for the years 2024,
2030 and 2040.

Participants
Sex-specific and age-specific population projections, national cancer incidence and exposure data.
Primary and secondary outcome measures: new cancer
cases attributable to SB and healthcare costs associated
with cancer cases attributable to SB in Germany for the
year 2024.

Results
Estimated numbers of cancers attributable to SB
are projected to be up to 7612 cases (6% of total cancer
cases) in 2024, up to 7899 cases (6%) in 2030 and up
to 8245 cases (6%) in 2040. The PAF attributable to SB
in women is 3% for breast cancer, 8% for colon cancer,
9% for both endometrial and ovarian cancers and 2%
for rectal cancer. In men, the PAF is 9% for colon cancer
and 3% for rectal cancer. In 2024, the estimated costs of
SB-attributable cancers are €270 million for colon cancer,
€51 million for rectal cancer, €234 million for breast
cancer and €242 million for female genital cancers.
Conclusions A considerable number of cancer cases can
be attributed to SB, which also imposes a large health
economic burden. Implementing effective prevention
measures, such as workplace, school or commuting
interventions, is needed to reduce the incidence of cancer
attributable to this modifiable risk factor.