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Novel 'Nano in Nano' Composites for Sustained Drug Delivery : Biodegradable Nanoparticles Encapsulated into Nanofiber Non-Wovens

Title data

Beck-Broichsitter, Moritz ; Thieme, Marcel ; Nguyen, Juliane ; Schmehl, Thomas ; Gessler, Tobias ; Seeger, Werner ; Agarwal, Seema ; Greiner, Andreas ; Kissel, Thomas:
Novel 'Nano in Nano' Composites for Sustained Drug Delivery : Biodegradable Nanoparticles Encapsulated into Nanofiber Non-Wovens.
In: Macromolecular Bioscience. Vol. 10 (8 December 2010) Issue 12 . - pp. 1527-1535.
ISSN 1616-5187
DOI: https://doi.org/10.1002/mabi.201000100

Official URL: Volltext

Project information

Project financing: Deutsche Forschungsgemeinschaft

Abstract in another language

Novel 'nano in nano' composites consisting of biodegradable polymer nanoparticles incorporated into polymer nanofibers may efficiently modulate drug delivery. This is shown here using a combination of model compound-loaded biodegradable nanoparticles encapsulated in electrospun fibers. The dye coumarin 6 is used as model compound for a drug in order to simulate drug release from loaded poly(lactide-co-glycolide) nanoparticles. Dye release from the nanoparticles occurs immediately in aqueous solution. Dye-loaded nanoparticles which are encapsulated by electrospun polymer nanofibers display a significantly retarded release.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: biodegradable; composite materials; controlled drug delivery; nanoparticles; nanofiber non-wovens
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 01 Apr 2015 07:35
Last Modified: 01 Apr 2015 07:35
URI: https://eref.uni-bayreuth.de/id/eprint/9551