Novel 'Nano in Nano' Composites for Sustained Drug Delivery : Biodegradable Nanoparticles Encapsulated into Nanofiber Non-Wovens

Titelangaben

Beck-Broichsitter, Moritz ; Thieme, Marcel ; Nguyen, Juliane ; Schmehl, Thomas ; Gessler, Tobias ; Seeger, Werner ; Agarwal, Seema ; Greiner, Andreas ; Kissel, Thomas:
Novel 'Nano in Nano' Composites for Sustained Drug Delivery : Biodegradable Nanoparticles Encapsulated into Nanofiber Non-Wovens.
In: Macromolecular Bioscience. Bd. 10 (2010) Heft 12 . - S. 1527-1535.
ISSN 1616-5195
DOI: https://doi.org/10.1002/mabi.201000100

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Abstract

Novel 'nano in nano' composites consisting of biodegradable polymer nanoparticles incorporated into polymer nanofibers may efficiently modulate drug delivery. This is shown here using a combination of model compound-loaded biodegradable nanoparticles encapsulated in electrospun fibers. The dye coumarin 6 is used as model compound for a drug in order to simulate drug release from loaded poly(lactide-co-glycolide) nanoparticles. Dye release from the nanoparticles occurs immediately in aqueous solution. Dye-loaded nanoparticles which are encapsulated by electrospun polymer nanofibers display a significantly retarded release.