Titlebar

Export bibliographic data
Literature by the same author
plus on the publication server
plus at Google Scholar

 

A Polymeric Drug Depot Based on 7-(2'-Methacryloyloxyethoxy)-4-methylcoumarin Copolymers for Photoinduced Release of 5-Fluorouracil Designed for the Treatment of Secondary Cataracts

Title data

Sinkel, Carsten ; Greiner, Andreas ; Agarwal, Seema:
A Polymeric Drug Depot Based on 7-(2'-Methacryloyloxyethoxy)-4-methylcoumarin Copolymers for Photoinduced Release of 5-Fluorouracil Designed for the Treatment of Secondary Cataracts.
In: Macromolecular Chemistry and Physics. Vol. 211 (1 September 2010) Issue 17 . - pp. 1857-1867.
ISSN 1521-3935
DOI: https://doi.org/10.1002/macp.201000206

Official URL: Volltext

Project information

Project financing: Bundesministerium für Bildung und Forschung

Abstract in another language

The synthesis of a polymeric, photoresponsive drug-delivery system on the basis of 4-methylcoumarin-side-chain-functionalized methacrylic copolymers with different degrees of functionalization is reported. Drug-release experiments in solution indicated a maximum release of 22 mu g of 5-fluorouracil per 1 mg of polymer. Polymer analogous photochemical drug immobilization does not lead to observable intermolecular cross-linking. Miscibility experiments with PMMA suggest that the bulk polymerization of homogeneous, transparent polymer sheets for intraocular lens fabrication, using MMA as the matrix monomer and incorporating the polymer-drug conjugates as a functional component, is possible.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: :coumarin linkers; 5-fluorouracil; photoresponsive polymers; polymeric drug depots
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 01 Apr 2015 09:14
Last Modified: 01 Apr 2015 09:14
URI: https://eref.uni-bayreuth.de/id/eprint/9554