A Polymeric Drug Depot Based on 7-(2'-Methacryloyloxyethoxy)-4-methylcoumarin Copolymers for Photoinduced Release of 5-Fluorouracil Designed for the Treatment of Secondary Cataracts

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Sinkel, Carsten ; Greiner, Andreas ; Agarwal, Seema:
A Polymeric Drug Depot Based on 7-(2'-Methacryloyloxyethoxy)-4-methylcoumarin Copolymers for Photoinduced Release of 5-Fluorouracil Designed for the Treatment of Secondary Cataracts.
In: Macromolecular Chemistry and Physics. Bd. 211 (2010) Heft 17 . - S. 1857-1867.
ISSN 1521-3935
DOI: https://doi.org/10.1002/macp.201000206

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Abstract

The synthesis of a polymeric, photoresponsive drug-delivery system on the basis of 4-methylcoumarin-side-chain-functionalized methacrylic copolymers with different degrees of functionalization is reported. Drug-release experiments in solution indicated a maximum release of 22 mu g of 5-fluorouracil per 1 mg of polymer. Polymer analogous photochemical drug immobilization does not lead to observable intermolecular cross-linking. Miscibility experiments with PMMA suggest that the bulk polymerization of homogeneous, transparent polymer sheets for intraocular lens fabrication, using MMA as the matrix monomer and incorporating the polymer-drug conjugates as a functional component, is possible.