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Hydrolytic and enzymatic degradation of liquid-crystalline aromatic/aliphatic copolyesters

Title data

Chen, Yiwang ; Jia, Zhihong ; Schaper, Andreas ; Kristiansen, Magnus ; Smith, Paul ; Wombacher, Ralf ; Wendorff, Joachim H. ; Greiner, Andreas:
Hydrolytic and enzymatic degradation of liquid-crystalline aromatic/aliphatic copolyesters.
In: Biomacromolecules. Vol. 5 (2004) Issue 1 . - pp. 11-16.
ISSN 1526-4602
DOI: https://doi.org/10.1021/bm034388c

Official URL: Volltext

Abstract in another language

Aromatic/aliphatic copolyesters containing hydrophilic moieties in the main chain or side chain were synthesized by bulk polycondensation of aromatic monomers without or with solubilizing substituents and aliphatic monomers. Hydrolytic and enzymatic degradation studies were carried out in vitro at 37degreesC in pH 7.4 phosphate buffer and in Tris-HCl buffer containing proteinase K. The results indicate that liquid-crystalline aromatic/aliphatic copolyesters are degradable hydrolytically as well as enzymatically. The change in composition and morphology of the polyester films were monitored by nuclear magnetic resonance and scanning electron microscopy. The results suggested that aromatic species and aliphatic moieties could be released into aqueous solution during hydrolytic degradation of aromatic/aliphatic copolyesters with ethyleneoxy groups on the side chain. Modifying aromatic species with hydrophilic groups in aromatic/aliphatic copolyesters was an efficient method to improve degradability and biocompatibility due to improved solubility of degradation products in aqueous solution. Mechanical tests indicated that the copolyesters exhibited good mechanical properties prior to degradation, which can be of relevance for bone tissue engineering.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: THERMOTROPIC AROMATIC/LACTIDE COPOLYESTERS; IN-VITRO DEGRADATION; LOW-MOLECULAR-WEIGHT; L-LACTIC ACID; TEREPHTHALIC ACID; POLYESTERS; COPOLYMER; INVITRO
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 01 Apr 2015 13:09
Last Modified: 01 Apr 2015 13:09
URI: https://eref.uni-bayreuth.de/id/eprint/9735