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Hydrolytic and enzymatic degradation of liquid-crystalline aromatic/aliphatic copolyesters

Titelangaben

Chen, Yiwang ; Jia, Zhihong ; Schaper, Andreas ; Kristiansen, Magnus ; Smith, Paul ; Wombacher, Ralf ; Wendorff, Joachim H. ; Greiner, Andreas:
Hydrolytic and enzymatic degradation of liquid-crystalline aromatic/aliphatic copolyesters.
In: Biomacromolecules. Bd. 5 (2004) Heft 1 . - S. 11-16.
ISSN 1526-4602
DOI: https://doi.org/10.1021/bm034388c

Volltext

Link zum Volltext (externe URL): Volltext

Abstract

Aromatic/aliphatic copolyesters containing hydrophilic moieties in the main chain or side chain were synthesized by bulk polycondensation of aromatic monomers without or with solubilizing substituents and aliphatic monomers. Hydrolytic and enzymatic degradation studies were carried out in vitro at 37degreesC in pH 7.4 phosphate buffer and in Tris-HCl buffer containing proteinase K. The results indicate that liquid-crystalline aromatic/aliphatic copolyesters are degradable hydrolytically as well as enzymatically. The change in composition and morphology of the polyester films were monitored by nuclear magnetic resonance and scanning electron microscopy. The results suggested that aromatic species and aliphatic moieties could be released into aqueous solution during hydrolytic degradation of aromatic/aliphatic copolyesters with ethyleneoxy groups on the side chain. Modifying aromatic species with hydrophilic groups in aromatic/aliphatic copolyesters was an efficient method to improve degradability and biocompatibility due to improved solubility of degradation products in aqueous solution. Mechanical tests indicated that the copolyesters exhibited good mechanical properties prior to degradation, which can be of relevance for bone tissue engineering.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Keywords: THERMOTROPIC AROMATIC/LACTIDE COPOLYESTERS; IN-VITRO DEGRADATION; LOW-MOLECULAR-WEIGHT; L-LACTIC ACID; TEREPHTHALIC ACID; POLYESTERS; COPOLYMER; INVITRO
Institutionen der Universität: Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie II > Lehrstuhl Makromolekulare Chemie II - Univ.-Prof. Dr. Andreas Greiner
Fakultäten
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie II
Titel an der UBT entstanden: Nein
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
Eingestellt am: 01 Apr 2015 13:09
Letzte Änderung: 01 Apr 2015 13:09
URI: https://eref.uni-bayreuth.de/id/eprint/9735