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Biocompatible Drug Delivery System for Photo-Triggered Controlled Release of 5-Fluorouracil

Title data

Jin, Qiao ; Mitschang, Fabian ; Agarwal, Seema:
Biocompatible Drug Delivery System for Photo-Triggered Controlled Release of 5-Fluorouracil.
In: Biomacromolecules. Vol. 12 (2011) Issue 10 . - pp. 3684-3691.
ISSN 1526-4602
DOI: https://doi.org/10.1021/bm2009125

Official URL: Volltext

Abstract in another language

The synthesis of a photo-triggered biocompatible drug delivery system on the basis of coumarin-functionalized block copolymers is reported. The coumarin-functionalized block copolymers poly(ethylene oxide)-b-poly(n-butyl methacrylate-co-4-methyl-7-(methacryloyl)oxyethyloxycoumarin)) (PEO-b-P(BMA- co-CMA)) were synthesized via atom transfer radical polymerization (ATRP). The micelle–drug conjugates were made by covalent bonding of anticancer drug 5-fluorouracil (5-FU) to the coumarin under UV irradiation at wavelength >310 nm. These micelle–drug conjugates possessed spherical morphology with diameters of 70 nm from TEM images. In vitro drug release experiments showed the controlled release of anticancer drug 5-FU from the micelle–drug conjugates under UV irradiation (254 nm). These micelle–drug conjugates also showed excellent biocompatibility by the in vitro cytotoxicity experiments. The results suggest that these micelle–drug conjugates could be a promising candidate for the delivery of anticancer agents with low side effects on normal cells and excellent therapeutic efficacy to cancer cells.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: PMID: 21863834
Keywords: CROSS-LINKED NANOGELS; POLYMERIC MICELLES; BLOCK-COPOLYMERS; DOXORUBICIN; NANOPARTICLES; PRODRUGS; TUMOR; CHEMOTHERAPY; AGENTS
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Profile Fields > Advanced Fields > Polymer and Colloid Science
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Profile Fields
Profile Fields > Advanced Fields
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 01 Apr 2015 13:01
Last Modified: 01 Apr 2015 13:01
URI: https://eref.uni-bayreuth.de/id/eprint/9801