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Synthesis, characterization and properties of a new polymerisable surfactant: 12-Methacryloyl dodecylphosphocholine

Title data

Seuring, Jan ; Reiss, Philipp ; Koert, Ulrich ; Agarwal, Seema:
Synthesis, characterization and properties of a new polymerisable surfactant: 12-Methacryloyl dodecylphosphocholine.
In: Chemistry and Physics of Lipids. Vol. 163 (May 2010) Issue 4–5 . - 367- 372.
ISSN 0009-3084
DOI: https://doi.org/10.1016/j.chemphyslip.2010.03.001

Official URL: Volltext

Abstract in another language

A new polymerizable surfactant, 12-methacryloyl dodecylphosphocholine (MDPC), has been synthesized using a three-step procedure in moderate yield. Phase transitions were characterized by {DSC} and phase behavior in water was determined by surface tension and polarizing microscopy. {MDPC} showed typical surfactant behavior and self-aggregated to micelles above a distinct concentration. The critical micelle concentration (CMC) of {MDPC} was determined to be 5 × 10−4 mol/L. {MDPC} showed mesomorphic properties between 75 and 86 °C as studied by differential scanning calorimetry (DSC). The formation of black lipid membranes was further investigated. The methacrylate functionalized {MDPC} could form a bilayer membrane (BLM) although it was very unstable (collapsed after 10–30 s). However, it was possible to form stable {BLMs} in mixture with non-polymerizable two chain phospholipids, i.e. asolectin and diphytanoyl phosphatidylcholine (DPhPC). Stable bilayers could be obtained up to a {MDPC} content of 50 mol. Gramicidin A was incorporated into MDPC/DPhPC membranes and exhibited ion-channel activity shown by single channel conductivity measurements.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Polymerizable surfactant; Phosphocholine; Ion channels; Gramicidin A
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Profile Fields > Advanced Fields > Polymer and Colloid Science
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Profile Fields
Profile Fields > Advanced Fields
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 07 Apr 2015 12:06
Last Modified: 07 Apr 2015 12:11
URI: https://eref.uni-bayreuth.de/id/eprint/9884