Synthesis of hydrolytically degradable aromatic polyesters with lactide moieties

Titelangaben

Haderlein, G. ; Schmidt, C. ; Wendorff, Joachim H. ; Greiner, Andreas:
Synthesis of hydrolytically degradable aromatic polyesters with lactide moieties.
In: Polymers for Advanced Technologies. Bd. 8 (1997) Heft 9 . - S. 568-573.
ISSN 1099-1581
DOI: https://doi.org/10.1002/(SICI)1099-1581(199709)8:9<568::AID-PAT721>3.0.CO;2-W

Volltext

Link zum Volltext (externe URL):

Abstract

A synthetic route to higher molecular weight processable polyesters with bisphenol A terephthalate/isophthalate moieties and lactide moieties which are of potential interest for tissue engineering is described. The combination of aliphatic and aromatic moieties is a promising concept for processable polyesters with potential sites for physiological degradation and improved mechanical properties. The molecular structure of the copolyesters prepared by melt condensation via an acid chloride route and incorporation of the lactide moieties by transesterification of an oligo DL-lactide was confirmed by infrared, H-1 and C-13 nuclear magnetic resonance spectroscopy as well as gel permeation chromatography. The thermal and mechanical properties of copoIyesters with different amounts of lactide moieties are reported and correlated with their composition. The reaction mechanism by transesterification was proved by a model reaction with a physical blend of the components and the hydrolytical behavior of the copolyesters under physiological conditions has been investigated. (C) 1997 by John Wiley & Sons, Ltd.