at Google ScholarTitle data
Behrens, Susanne ; Maier, Raimund ; de Cock, Hans ; Schmid, Franz X. ; Gross, Carol A.:
The SurA periplasmic PPIase lacking its parvulin domains functions in vivo and has chaperone activity.
In: The EMBO Journal.
Vol. 20
(2001)
Issue 1-2
.
- pp. 285-294.
ISSN 1460-2075
DOI: https://doi.org/10.1093/emboj/20.1.285
Abstract in another language
The Escherichia coli periplasmic peptidyl-prolyl isomerase (PPIase) SurA is involved in the maturation of outer membrane porins. SurA consists of a substantial N-terminal region, two iterative parvulin-like domains and a C-terminal tail. Here we show that a variant of SurA lacking both parvulin-like domains exhibits a PPIase-independent chaperone-like activity in vitro and almost completely complements the in vivo function of intact SurA. SurA interacts preferentially (>50-fold) with in vitro synthesized porins over other similarly sized proteins, leading us to suggest that the chaperone-like function of SurA preferentially facilitates maturation of outer membrane proteins.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Additional notes: | PubMed-ID: 9029143 |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Professor Biochemistry - Univ.-Prof. Dr. Franz Xaver Schmid Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Professorship Biochemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors |
| Result of work at the UBT: | Yes |
| DDC Subjects: | 500 Science > 540 Chemistry |
| Date Deposited: | 28 May 2015 07:20 |
| Last Modified: | 28 Feb 2023 13:37 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/14380 |