A comparison of the effects of fibre alignment of smooth and textured fibres in electrospun membranes on fibroblast cell adhesion

Title data

Truong, Yen B. ; Glattauer, Veronica ; Lang, Gregor ; Hands, Karen ; Kyratzis, Ilias L. ; Werkmeister, Jerome A. ; Ramshaw, John A. M.:
A comparison of the effects of fibre alignment of smooth and textured fibres in electrospun membranes on fibroblast cell adhesion.
In: Biomedical Materials. Vol. 5 (2010) Issue 2 . - 025005.
ISSN 1748-6041
DOI: https://doi.org/10.1088/1748-6041/5/2/025005

Official URL:

Abstract in another language

A polyester polycaprolactone-based polyurethane elastomer (PU) and poly-(L-lactide) (PLLA), two common biomaterials, were electrospun to produce membranes with fibres either randomly orientated or aligned. PU was used to produce membranes consisting of smooth fibres. PLLA was used to prepare fibres with a textured surface. Contact angle measurements of the PU and PLLA cast films reveal that they were both below 90 degrees and fully wetted in less than 60 s. These membranes were investigated for the effect of fibre topography and fibre alignment on cell adhesion, using mouse L929 fibroblasts. It was found that the alignment of electrospun fibres controls the directional spreading of fibroblast independent of fibre being smooth or textured.

Further data

Item Type:	Article in a journal
Refereed:	Yes
Keywords:	surface-morphology; scaffolds; proliferation; topography; diameter
Institutions of the University:	Faculties > Faculty of Engineering Science > Former Professors > Junior Professor Biopolymer Processing - Juniorprof. Dr.-Ing. Gregor Lang Faculties Faculties > Faculty of Engineering Science Faculties > Faculty of Engineering Science > Junior Professor Biopolymer Processing Faculties > Faculty of Engineering Science > Former Professors
Result of work at the UBT:	No
DDC Subjects:	600 Technology, medicine, applied sciences > 610 Medicine and health 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited:	08 Mar 2016 08:14
Last Modified:	01 Jun 2023 11:42
URI:	https://eref.uni-bayreuth.de/id/eprint/31388