at Google ScholarTitle data
Ziegler, Thea ; Schumacher, Charlotte Helene ; Möglich, Andreas:
Guidelines for Photoreceptor Engineering.
In: Kianianmomeni, Arash
(ed.):
Optogenetics : methods and protocols. -
New York, NY
: Humana Press
,
2016
. - pp. 389-403
. - (Methods in Molecular Biology
; 1408
)
ISBN 978-1-4939-3510-9
DOI: https://doi.org/10.1007/978-1-4939-3512-3_27
Abstract in another language
Sensory photoreceptors underpin optogenetics by mediating the noninvasive and reversible perturbation of living cells by light with unprecedented temporal and spatial resolution. Spurred by seminal optogenetic applications of natural photoreceptors, the engineering of photoreceptors has recently garnered wide interest and has led to the construction of a broad palette of novel light-regulated actuators. Photoreceptors are modularly built of photosensors that receive light signals, and of effectors that carry out specific cellular functions. These modules have to be precisely connected to allow efficient communication, such that light stimuli are relayed from photosensor to effector. The engineering of photoreceptors benefits from a thorough understanding of the underlying signaling mechanisms. This chapter gives a brief overview of key characteristics and signal-transduction mechanisms of sensory photoreceptors. Adaptation of these concepts in photoreceptor engineering has enabled the generation of novel optogenetic tools that greatly transcend the repertoire of natural photoreceptors.
Further data
| Item Type: | Article in a book |
|---|---|
| Refereed: | Yes |
| Additional notes: | PubMed-ID: 26965138 |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Andreas Möglich Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Professorship Biochemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry |
| Result of work at the UBT: | No |
| DDC Subjects: | 500 Science 500 Science > 540 Chemistry |
| Date Deposited: | 21 Sep 2016 06:35 |
| Last Modified: | 23 Apr 2024 11:08 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/34755 |