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Schmidt, Stephan ; van der Gucht, Jasper ; Biesheuvel, P. Maarten ; Weinkamer, Richard ; Helfer, Emmanuele ; Fery, Andreas:
Non-Gaussian curvature distribution of actin-propelled biomimetic colloid trajectories.
In: European Biophysics Journal with Biophysics Letters.
Bd. 37
(2008)
Heft 8
.
- S. 1361-1366.
ISSN 1432-1017
DOI: https://doi.org/10.1007/s00249-008-0340-x
Abstract
We analyze the motion of colloids propelled by a comet-like tail of polymerizing actin filaments. The curvature of the particle trajectories deviates strongly from a Gaussian distribution, implying that the underlying microscopic processes are fluctuating in a non-independent manner. Trajectories for beads of different size all showed the same non-Gaussian behavior, while the mean curvature decreased weakly with size. A stochastic simulation that includes nucleation, force-dependent dissociation, growth, and capping of filaments, shows that the non-Gaussian curvature distribution can be explained by a positive feedback mechanism in which attached chains under higher tension are more likely to snap.