Heterocycle biosynthesis via C-H functionalization

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Hahn, Frank:
Heterocycle biosynthesis via C-H functionalization.
In: Nature Catalysis. Bd. 1 (2018) . - S. 905-906.
ISSN 2520-1158
DOI: https://doi.org/10.1038/s41929-018-0194-2

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Abstract

The biosynthesis of the pharmacophoric tetrahydropyran of the clinically important antibiotic mupirocin remained enigmatic for a long time. Now, research shows that this ring is formed by a unique epoxidation–epoxide-opening cascade starting from a non-activated alkane.