Structure of Amyloid A4-(1-40)-Peptide of Alzheimer's Disease

Titelangaben

Sticht, Heinrich ; Bayer, Peter ; Willbold, Dieter ; Dames, Sonja ; Hilbich, Caroline ; Beyreuther, Konrad ; Frank, Rainer W. ; Rösch, Paul:
Structure of Amyloid A4-(1-40)-Peptide of Alzheimer's Disease.
In: European Journal of Biochemistry. Bd. 233 (1995) Heft 1 . - S. 293-298.
ISSN 1432-1033
DOI: https://doi.org/10.1111/j.1432-1033.1995.293_1.x

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Abstract

One of the principal peptide components of the amyloid plaque deposits of Alzheimer's disease in humans is the 40-amino-acid peptide 8-amyloid A4-(1-40)-peptide. The full-length A4-(I-40)-peptide was chemically synthesized and the sulution structure determined by two-dimensional nuclear magnetic resonance spectroscopy and restrained molecular-dynamics calculations. Synthetic human A4-(1-40)-peptide was soluble and non-aggregating for several days in 40% (by vol.) trifluoroethanol/water. All spin systems could ...