Pipecolic acid derivatives as small-molecule inhibitors of the Legionella MIP protein

Title data

Juli, Christina ; Sippel, Martin ; Jäger, Jens ; Thiele, Alexandra ; Weiwad, Matthias ; Schweimer, Kristian ; Rösch, Paul ; Steinert, Michael ; Sotriffer, Christoph ; Holzgrabe, Ulrike:
Pipecolic acid derivatives as small-molecule inhibitors of the Legionella MIP protein.
In: Journal of Medicinal Chemistry. Vol. 54 (2011) Issue 1 . - pp. 277-283.
ISSN 1520-4804
DOI: https://doi.org/10.1021/jm101156y

Official URL:

Abstract in another language

The macrophage infectivity potentiator (MIP) protein is a major virulence factor of Legionella pneumophila, the causative agent of Legionnaires' disease. MIP belongs to the FK506-binding proteins (FKBP) and is necessary for optimal intracellular survival and lung tissue dissemination of L. pneumophila. We aimed to identify new small-molecule inhibitors of MIP by starting from known FKBP12 ligands. Computational analysis, synthesis, and biological testing of pipecolic acid derivatives revealed a promising scaffold for new MIP inhibitors.

Further data

Item Type:	Article in a journal
Refereed:	Yes
Institutions of the University:	Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry with an Emphasis on Biophysical Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Biopolymers - Univ.-Prof. Dr. Paul Rösch Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Biopolymers - Apl. Prof. Dr. Birgitta Wöhrl Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry with an Emphasis on Biophysical Chemistry > Chair Biochemistry with an Emphasis on Biophysical Chemistry - Univ.-Prof. Dr. Janosch Hennig
Result of work at the UBT:	Yes
DDC Subjects:	500 Science 500 Science > 500 Natural sciences 500 Science > 540 Chemistry 500 Science > 570 Life sciences, biology
Date Deposited:	21 Jan 2015 07:48
Last Modified:	22 Dec 2023 12:24
URI:	https://eref.uni-bayreuth.de/id/eprint/5334