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4D biofabrication of fibrous artificial nerve graft for neuron regeneration

Title data

Apsite, Indra ; Constante Ibarra, Gissela Katherine ; Dulle, Martin ; Vogt, Lena ; Caspari, Anja ; Boccaccini, Aldo R. ; Synytska, Alla ; Salehi, Sahar ; Ionov, Leonid:
4D biofabrication of fibrous artificial nerve graft for neuron regeneration.
In: Biofabrication. Vol. 12 (2020) Issue 3 . - 035027.
ISSN 1758-5082

Abstract in another language

In this paper, we describe the application of the 4D biofabrication approach for the fabrication of artificial nerve graft. Bilayer scaffolds consisting of uniaxially aligned polycaprolactonepoly(glycerol sebacate) (PCL-PGS) and randomly aligned methacrylated hyaluronic acid (HA-MA) fibers were fabricated using electrospinning and further used for the culture of PC-12 neuron cells. Tubular structures form instantly after immersion of fibrous bilayer in an aqueous buffer and the diameter of obtained tubes can be controlled by changing bilayer parameters such as the thickness of each layer, overall bilayer thickness, and medium counterion concentration. Designed scaffolds showed a self-folded scroll-like structure with high stability after four weeks of real-time degradation. The significance of this research is in the fabrication of a tuneable tubular nerve guide conduits that can simplify the current existing clinical treatment of neural injuries.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: electrospinning; self-folding; nerve guide conduits; 4D biofabrication; neuron cells
Institutions of the University: Faculties > Faculty of Engineering Science > Professor Biofabrication > Professor Biofabrication - Univ.-Prof. Dr. Leonid Ionov
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Professor Biofabrication
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 540 Chemistry
600 Technology, medicine, applied sciences > 600 Technology
Date Deposited: 29 May 2020 07:44
Last Modified: 30 May 2023 11:34