Foamy Virus Gag p71-p68 Cleavage Is Required for Template Switch of the Reverse Transcriptase

Title data

Spannaus, Ralf ; Schneider, Anna ; Hartl, Maximilian J. ; Wöhrl, Birgitta M. ; Bodem, Jochen:
Foamy Virus Gag p71-p68 Cleavage Is Required for Template Switch of the Reverse Transcriptase.
In: Journal of Virology. Vol. 87 (2013) Issue 13 . - pp. 7774-7776.
ISSN 1098-5514
DOI: https://doi.org/10.1128/JVI.00833-13

Official URL:

Abstract in another language

In contrast to orthoretroviruses, processing of foamy viral p71 Gag is limited to a single cleavage site. Nevertheless, Gag maturation is essential for infectivity, but deletion of p3 results in a modest drop in infectivity. Here, we show that Gag processing of p71 to p68 and p3 is essential for full-length cDNA synthesis, while inactivation of Gag cleavage results in cDNAs containing only the RU5 region; cDNAs encompassing the U3 region were almost undetectable.

Further data

Item Type:	Article in a journal
Refereed:	Yes
Institutions of the University:	Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry with an Emphasis on Biophysical Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Biopolymers - Univ.-Prof. Dr. Paul Rösch Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Biopolymers - Apl. Prof. Dr. Birgitta Wöhrl
Result of work at the UBT:	Yes
DDC Subjects:	500 Science 500 Science > 500 Natural sciences 500 Science > 540 Chemistry 500 Science > 570 Life sciences, biology
Date Deposited:	15 Jan 2015 07:20
Last Modified:	26 Jul 2022 12:01
URI:	https://eref.uni-bayreuth.de/id/eprint/5561