at Google ScholarTitle data
Janczura, Joanna ; Balcerek, Michał ; Burnecki, Krzysztof ; Sabri, Adal ; Weiss, Matthias ; Krapf, Diego:
Identifying heterogeneous diffusion states in the cytoplasm by a hidden Markov model.
In: New Journal of Physics.
Vol. 23
(2021)
Issue 5
.
- 053018.
ISSN 1367-2630
DOI: https://doi.org/10.1088/1367-2630/abf204
Abstract in another language
Diffusion of nanoparticles in the cytoplasm of live cells has frequently been reported to exhibit an anomalous and even heterogeneous character, i.e. particles seem to switch gears during their journey. Here we show by means of a hidden Markov model that individual trajectories of quantum dots in the cytoplasm of living cultured cells feature a dichotomous switching between two distinct mobility states with an overall subdiffusive mode of motion of the fractional Brownian motion (FBM) type. Using the extracted features of experimental trajectories as input for simulations of different variants of a two-state FBM model, we show that the trajectory-intrinsic and the ensemble-wise heterogeneity in the experimental data is mostly due to variations in the (local) transport coefficients, with only minor contributions due to locally varying anomaly exponents. Altogether, our approach shows that diffusion heterogeneities can be faithfully extracted and quantified from fairly short trajectories obtained by single-particle tracking in highly complex media.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties Faculties > Faculty of Mathematics, Physics und Computer Science Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Chair Experimental Physics I - Physics of Living Matter Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Chair Experimental Physics I - Physics of Living Matter > Chair Experimental Physics I - Physics of Living Matter - Univ.-Prof. Dr. Matthias Weiss Profile Fields > Advanced Fields > Nonlinear Dynamics Profile Fields Profile Fields > Advanced Fields |
| Result of work at the UBT: | Yes |
| DDC Subjects: | 500 Science > 530 Physics 500 Science > 570 Life sciences, biology |
| Date Deposited: | 17 May 2021 09:37 |
| Last Modified: | 13 Dec 2022 08:06 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/65200 |