bei Google ScholarTitelangaben
Kaliman, Sara ; Hubert, Maxime ; Wollnik, Carina ; Nuić, Lovro ; Vurnek, Damir ; Gehrer, Simone ; Lovrić, Jakov ; Dudziak, Diana ; Rehfeldt, Florian ; Smith, Ana-Sunčana:
Mechanical Regulation of Epithelial Tissue Homeostasis.
In: Physical Review X.
Bd. 11
(2021)
Heft 3
.
- 031029.
ISSN 2160-3308
DOI: https://doi.org/10.1103/PhysRevX.11.031029
Abstract
Despite recent efforts to understand homeostasis in epithelial tissues, there are many unknowns surrounding this steady state. It is considered to be regulated by mechanoresponse, but unlike for single cells, this idea remains heavily debated for tissues. Here, we show that changes in matrix stiffness induce a nonequilibrium transition from tubular to squamous Madin-Darby Canine Kidney II tissues. Nonetheless, despite different cell morphologies and densities, all homeostatic tissues display equivalent topologies, which, hence, must be actively targeted and regulated. On the contrary, the mechanoresponse induces dramatic changes in the large-scale organization of the colonies. On stiff gels, this yields an unreported cooperative state of motile cells displaying higher densities than in the arrested homeostatic state, which suggests a more complex relation between cell density and motility than previously anticipated. Our results unequivocally relate the mechanosensitive properties of individual cells to the evolving macroscopic structures, an effect that could be important for understanding the emergent pathologies of living tissues.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Mathematik, Physik und Informatik > Physikalisches Institut > Lehrstuhl Experimentalphysik I - Physik lebender Materie > Lehrstuhl Experimentalphysik I - Physik lebender Materie - Univ.-Prof. Dr. Matthias Weiss Fakultäten Fakultäten > Fakultät für Mathematik, Physik und Informatik Fakultäten > Fakultät für Mathematik, Physik und Informatik > Physikalisches Institut Fakultäten > Fakultät für Mathematik, Physik und Informatik > Physikalisches Institut > Lehrstuhl Experimentalphysik I - Physik lebender Materie |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 530 Physik 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie |
| Eingestellt am: | 24 Aug 2021 07:08 |
| Letzte Änderung: | 17 Mär 2022 13:32 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/66829 |