at Google ScholarTitle data
Williams, Felix Preston ; Haubrich, Kevin ; Perez-Borrajero, Cecilia ; Hennig, Janosch:
Emerging RNA-binding roles in the TRIM family of ubiquitin ligases.
In: Biological Chemistry.
Vol. 400
(2019)
Issue 11
.
- pp. 1443-1464.
ISSN 1437-4315
DOI: https://doi.org/10.1515/hsz-2019-0158
Abstract in another language
TRIM proteins constitute a large, diverse and ancient protein family which play a key role in processes including cellular differentiation, autophagy, apoptosis, DNA repair, and tumour suppression. Mostly known and studied through the lens of their ubiquitination activity as E3 ligases, it has recently emerged that many of these proteins are involved in direct RNA binding through their NHL or PRY/SPRY domains. We summarise the current knowledge concerning the mechanism of RNA binding by TRIM proteins and its biological role. We discuss how RNA-binding relates to their previously described functions such as E3 ubiquitin ligase activity, and we will consider the potential role of enrichment in membrane-less organelles.