at Google ScholarTitle data
Bringmann, Gerhard ; Breuning, Matthias ; Tasler, Stefan:
The Lactone Concept : An Efficient Pathway to Axially Chiral Natural Products and Useful Reagents.
In: Synthesis.
(1999)
Issue 4
.
- pp. 525-558.
ISSN 0039-7881
DOI: https://doi.org/10.1055/s-1999-3435
Abstract in another language
A highly efficient concept for the stereoselective synthesis of axially chiral biaryl target molecules is presented: the atroposelective ring cleavage of configurationally unstable lactone-bridged biaryls. The method has almost no restrictions concerning the substitution pattern, works even for substrates with high steric hindrance at the ortho-position(s) of the axis, and allows the optional, atropo-divergent preparation of each atropisomer from the same biaryl lactone precursor and a recycling of the undesired minor product in the sense of a chiral economy. A brpad series of successful application in natural product and ligand syntheses underlines the high value of the method.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Keywords: | axial chirality; biaryl natural products; biaryl ligands and reagents; atropo-divergent synthesis; lactone-bridged biaryls |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Professor Organic Chemistry > Professor Organic Chemistry - Univ.-Prof. Dr. Matthias Breuning Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Professor Organic Chemistry |
| Result of work at the UBT: | No |
| DDC Subjects: | 500 Science > 540 Chemistry |
| Date Deposited: | 12 Jan 2022 10:35 |
| Last Modified: | 12 Jan 2022 10:35 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/68339 |