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Fibrous Scaffolds for Muscle Tissue Engineering Based on Touch‐Spun Poly(Ester‐Urethane) Elastomer

Titelangaben

Uribe Gómez, Juan Manuel ; Schönfeld, Dennis ; Posada Murcia, Andrés ; Roland, Michel-Manuel ; Caspari, Anja ; Synytska, Alla ; Salehi, Sahar ; Pretsch, Thorsten ; Ionov, Leonid:
Fibrous Scaffolds for Muscle Tissue Engineering Based on Touch‐Spun Poly(Ester‐Urethane) Elastomer.
In: Macromolecular Bioscience. Bd. 22 (2022) Heft 4 . - 2100427.
ISSN 1616-5195
DOI: https://doi.org/10.1002/mabi.202100427

Volltext

Link zum Volltext (externe URL): Volltext

Angaben zu Projekten

Projektfinanzierung: Deutsche Forschungsgemeinschaft
DFG IO 68/14-1
DFG IO 68/17-1
DFG SA 3575/1-1

Abstract

Development of fiber-spinning technologies and materials with proper mechanical properties is highly important for the manufacturing of aligned fibrous scaffolds mimicking structure of the muscle tissues. Here, the authors report touch spinning of a thermoplastic poly(1,4-butylene adipate)-based polyurethane elastomer, obtained via solvent-free polymerization. This polymer possesses a combination of important advantages such as 1) low elastic modulus in the range of a few MPa, 2) good recovery ratio and 3) resilience, 4) processability, 5) nontoxicity, 6) biocompatibility, and 7) biodegradability that makes it suitable for fabrication of structures mimicking extracellular matrix of muscle tissue. Touch spinning allows fast and precise deposition of highly aligned micro- and nano-fibers without use of high voltage. C2C12 myoblasts readily align along soft polymer fibers and demonstrate high viability as well as proliferation that make proposed combination of polymer and fabrication method highly suitable for engineering skeletal muscles.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Keywords: biofabrication; microfibers; poly(ester-urethane); skeletal muscles; touchspinning
Institutionen der Universität: Fakultäten > Fakultät für Ingenieurwissenschaften > Professur Biofabrikation
Fakultäten > Fakultät für Ingenieurwissenschaften > Professur Biofabrikation > Professur Biofabrikation - Univ.-Prof. Dr. Leonid Ionov
Fakultäten
Fakultäten > Fakultät für Ingenieurwissenschaften
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften
500 Naturwissenschaften und Mathematik > 540 Chemie
500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
Eingestellt am: 19 Jan 2022 10:04
Letzte Änderung: 18 Okt 2023 11:20
URI: https://eref.uni-bayreuth.de/id/eprint/68416