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Planer-Friedrich, Britta ; Kerl, Carolin F. ; Colina Blanco, Andrea Ester ; Clemens, Stephan:
Dimethylated Thioarsenates : A Potentially Dangerous Blind Spot in Current Worldwide Regulatory Limits for Arsenic in Rice.
In: Journal of Agricultural and Food Chemistry.
Bd. 70
(2022)
Heft 31
.
- S. 9610-9618.
ISSN 0021-8561
DOI: https://doi.org/10.1021/acs.jafc.2c02425
Abstract
Arsenic (As) occurrence in rice is a serious human health threat. Worldwide, regulations typically limit only carcinogenic inorganic As, but not possibly carcinogenic dimethylated oxyarsenate (DMA). However, there is emerging evidence that “DMA”, determined by routine acid-based extraction and analysis, hides a substantial share of dimethylated thioarsenates that have similar or higher cytotoxicities than arsenite. Risk assessments characterizing the in vivo toxicity of rice-derived dimethylated thioarsenates are urgently needed. In the meantime, either more sophisticated methods based on enzymatic extraction and separation of dimethylated oxy- and thioarsenates have to become mandatory or total As should be regulated.