Engineering Fluorescent Gold Nanoclusters Using Xanthate-Functionalized Hydrophilic Polymers : Toward Enhanced Monodispersity and Stability

Title data

Deepagan, Veerasikku Gopal ; Leiske, Meike N. ; Fletcher, Nicholas L. ; Rudd, David ; Tieu, Terence ; Kirkwood, Nicholas ; Thurecht, Kristofer J. ; Kempe, Kristian ; Voelcker, Nicolas H. ; Cifuentes-Rius, Anna:
Engineering Fluorescent Gold Nanoclusters Using Xanthate-Functionalized Hydrophilic Polymers : Toward Enhanced Monodispersity and Stability.
In: Nano Letters. Vol. 21 (2021) Issue 1 . - pp. 476-484.
ISSN 1530-6992
DOI: https://doi.org/10.1021/acs.nanolett.0c03930

Official URL:

Abstract in another language

We introduce xanthate-functionalized poly(cyclic imino ethers)s (PCIEs), specifically poly(2-ethyl-2-oxazoline) and poly(2-ethyl-2-oxazine) given their stealth characteristics, as an attractive alternative to conventional thiol-based ligands for the synthesis of highly monodisperse and fluorescent gold nanoclusters (AuNCs). The xanthate in the PCIEs interacts with Au ions, acting as a well-controlled template for the direct formation of PCIE-AuNCs. This method yields red-emitting AuNCs with a narrow emission peak (λem = 645 nm), good quantum yield (4.3–4.8%), long fluorescence decay time (∼722–844 ns), and unprecedented product yield (>98%). The PCIE-AuNCs exhibit long-term colloidal stability, biocompatibility, and antifouling properties, enabling a prolonged blood circulation, lower nonspecific accumulation in major organs, and better renal clearance when compared with AuNCs without polymer coating. The advances made here in the synthesis of metal nanoclusters using xanthate-functionalized PCIEs could propel the production of highly monodisperse, biocompatible, and renally clearable nanoprobes in large-scale for different theranostic applications.

Further data

Item Type:	Article in a journal
Refereed:	Yes
Keywords:	gold nanoclusters; fluorescence; xanthate; charge transfer; monodispersity; poly(2-oxazoline)
Institutions of the University:	Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Junior Professor Sustainable and Functional Polymer Systems > Junior Professor Sustainable and Functional Polymer Systems - Juniorprof. Dr. Meike Leiske Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Junior Professor Sustainable and Functional Polymer Systems
Result of work at the UBT:	No
DDC Subjects:	500 Science > 540 Chemistry
Date Deposited:	18 Jan 2023 14:41
Last Modified:	13 Mar 2023 08:44
URI:	https://eref.uni-bayreuth.de/id/eprint/73441