Institutionen der Universität Bayreuth
Juniorprofessur Nachhaltige und funktionale Polymersysteme - Juniorprof. Dr. Meike Leiske

Lutz, Theresa M. ; De Breuck, Jonas ; Salehi, Sahar ; Leiske, Meike N.:
Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications.
In: Advanced Functional Materials. (28 Juli 2025) . - e13765.
DOI: https://doi.org/10.1002/adfm.202513765

Schumann, Katja P. ; Lutz, Theresa M. ; Leiske, Meike N.:
The Copolymerization Performance of 2‐Cyclopropyl‐2‐Oxazoline and 2‐Cyclopropyl‐2‐Oxazine Contributes to Tunable Temperature‐Responsive (Co)Polymer Characteristics.
In: Journal of Polymer Science. (28 April 2025) .
DOI: https://doi.org/10.1002/pol.20241179

Lutz, Theresa M. ; Braksch, Cevin P. ; De Breuck, Jonas ; Hartlieb, Matthias ; Leiske, Meike N.:
Bio‐Inspired, Zwitterionic Copolymers with Amphiphilic Character.
In: Macromolecular Rapid Communications. (27 März 2025) . - 2401099.
DOI: https://doi.org/10.1002/marc.202401099

Traeger, Anja ; Leiske, Meike N.:
The Whole Is Greater than the Sum of Its Parts : Challenges and Perspectives in Polyelectrolytes.
In: Biomacromolecules. Bd. 26 (2025) Heft 1 . - S. 5-32.
DOI: https://doi.org/10.1021/acs.biomac.4c01061

De Breuck, Jonas ; Jérôme, Valérie ; Freitag, Ruth ; Leiske, Meike N.:
Zwitterionic Amino-Acid-Derived Polyacrylamides with a Betaine Twist : Synthesis and Characterization.
In: Macromolecular Rapid Communications. Bd. 46 (2025) Heft 1 . - 2400623.
DOI: https://doi.org/10.1002/marc.202400623

De Breuck, Jonas ; Streiber, Michael ; Ringleb, Michael ; Schröder, Dennis ; Herzog, Natascha ; Schubert, Ulrich S. ; Zechel, Stefan ; Traeger, Anja ; Leiske, Meike N.:
Amino-Acid-Derived Anionic Polyacrylamides with Tailored Hydrophobicity : Physicochemical Properties and Cellular Interactions.
In: ACS Polymers Au. Bd. 4 (2024) Heft 3 . - S. 222-234.
DOI: https://doi.org/10.1021/acspolymersau.3c00048

Lehnen, Anne-Catherine ; Kogikoski Jr., Sergio ; Stensitzki, Till ; AlSawaf, Ahmad ; Bapolisi, Alain M. ; Wolff, Martin ; De Breuck, Jonas ; Müller-Werkmeister, Henrike M. ; Chiantia, Salvatore ; Bald, Ilko ; Leiske, Meike N. ; Hartlieb, Matthias:
Anisotropy in Antimicrobial Bottle Brush Copolymers and Its Influence on Biological Activity.
In: Advanced Functional Materials. Bd. 34 (2024) Heft 10 . - 2312651.
DOI: https://doi.org/10.1002/adfm.202312651

Yu, Peitao ; Sedlačík, Tomáš ; Parmentier, Laurens ; Jerca, Florica Adriana ; Jerca, Valentin Victor ; Van Vlierberghe, Sandra ; Leiske, Meike N. ; Hoogenboom, Richard:
Degradable Cell-Adhesive Hybrid Hydrogels by Cross-Linking of Gelatin with Poly(2-isopropenyl-2-oxazoline).
In: Biomacromolecules. Bd. 25 (2024) Heft 8 . - S. 5332-5342.
DOI: https://doi.org/10.1021/acs.biomac.4c00743

Mazrad, Zihnil A. I. ; Refaat, Ahmed ; Morrow, Joshua P. ; Voelcker, Nicolas H. ; Nicolazzo, Joseph A. ; Leiske, Meike N. ; Kempe, Kristian:
Folic Acid-Conjugated Brush Polymers Show Enhanced Blood–Brain Barrier Crossing in Static and Dynamic In Vitro Models Toward Brain Cancer Targeting Therapy.
In: ACS Biomaterials Science & Engineering. Bd. 10 (2024) Heft 5 . - S. 2894-2910.
DOI: https://doi.org/10.1021/acsbiomaterials.3c01650

Merckx, Ronald ; Dhaware, Vinita ; Leiske, Meike N. ; De Clerck, Karen ; Hoogenboom, Richard:
Reactive Nanofiber Networks from a Chemistry Perspective.
In: Chemistry of Materials. Bd. 36 (2024) Heft 19 . - S. 9189-9206.
DOI: https://doi.org/10.1021/acs.chemmater.4c00277

Braksch, Cevin P. ; Lehnen, Anne-Catherine ; Bapolisi, Alain M. ; Gurke, Johannes ; De Breuck, Jonas ; Leiske, Meike N. ; Hartlieb, Matthias:
Staphylococcus aureus selective antimicrobial polymers based on an arginine-derived monomer.
In: Journal of Polymer Science. Bd. 62 (2024) Heft 1 . - S. 132-145.
DOI: https://doi.org/10.1002/pol.20230591

Mapfumo, Prosper P. ; Solomun, Jana I. ; Becker, Friedrich ; Moek, Elisabeth ; Leiske, Meike N. ; Rudolph, Lenhard K. ; Brendel, Johannes C. ; Traeger, Anja:
Vitamin B3 Containing Polymers for Nanodelivery.
In: Macromolecular Bioscience. Bd. 24 (2024) Heft 7 . - 2400002.
DOI: https://doi.org/10.1002/mabi.202400002

Leiske, Meike N. ; De Geest, Bruno G. ; Hoogenboom, Richard:
Impact of the polymer backbone chemistry on interactions of amino-acid-derived zwitterionic polymers with cells.
In: Bioactive Materials. Bd. 24 (2023) . - S. 524-534.
DOI: https://doi.org/10.1016/j.bioactmat.2023.01.005

Leiske, Meike N.:
Poly(2-oxazoline)-derived star-shaped polymers as potential materials for biomedical applications : A review.
In: European Polymer Journal. Bd. 185 (2023) . - 111832.
DOI: https://doi.org/10.1016/j.eurpolymj.2023.111832

Leiske, Meike N. ; Künneth, Christopher ; De Breuck, Jonas ; De Geest, Bruno G. ; Hoogenboom, Richard:
Amphiphilic Zwitterionic Bioderived Block Copolymers from Glutamic Acid and Cholesterol : Ability to Form Nanoparticles and Serve as Vectors for the Delivery of 6-Mercaptopurine.
In: Macromolecular Chemistry and Physics. Bd. 224 (2023) Heft 24 . - 2300200.
DOI: https://doi.org/10.1002/macp.202300200

Merckx, Ronald ; Becelaere, Jana ; Schoolaert, Ella ; Frateur, Olmo ; Leiske, Meike N. ; Peeters, Daniël ; Jerca, Florica Adriana ; Jerca, Valentin Victor ; De Clerck, Karen ; Hoogenboom, Richard:
Poly(2-isoproprenyl-2-oxazoline)-Based Reactive Hydrophilic Cross-Linked Nanofiber Networks as the Basis for Colorimetric Continuous Meat Freshness Monitoring Sensors.
In: Chemistry of Materials. Bd. 35 (2023) Heft 17 . - S. 7079-7093.
DOI: https://doi.org/10.1021/acs.chemmater.3c01355

Van Guyse, Joachim F. R. ; Leiske, Meike N. ; Verjans, Jente ; Bernhard, Yann ; Hoogenboom, Richard:
Accelerated Post-Polymerization Amidation of Polymers with Side-Chain Ester Groups by Intramolecular Activation.
In: Angewandte Chemie International Edition. Bd. 61 (2022) Heft 29 . - e202201781.
DOI: https://doi.org/10.1002/anie.202201781

Ma, Z. ; Wong, S. W. ; Forgham, H. ; Esser, L. ; Lai, M. ; Leiske, Meike N. ; Kempe, K. ; Sharbeen, G. ; Youkhana, J. ; Mansfeld, F. ; Quinn, J. F. ; Phillips, P. A. ; Davis, T. P. ; Kavallaris, M. ; McCarroll, J. A.:
Aerosol delivery of star polymer-siRNA nanoparticles as a therapeutic strategy to inhibit lung tumor growth.
In: Biomaterials. Bd. 285 (2022) . - 121539.
DOI: https://doi.org/10.1016/j.biomaterials.2022.121539

Leiske, Meike N. ; Kempe, Kristian:
A Guideline for the Synthesis of Amino-Acid-Functionalized Monomers and Their Polymerizations.
In: Macromolecular Rapid Communications. Bd. 43 (2022) Heft 2 . - 2100615.
DOI: https://doi.org/10.1002/marc.202100615

Rajesh, Sarigama ; Leiske, Meike N. ; Leitch, Victoria ; Zhai, Jiali ; Drummond, Calum J. ; Kempe, Kristian ; Tran, Nhiem:
Lipidic poly(2-oxazoline)s as PEG replacement steric stabilisers for cubosomes.
In: Journal of Colloid and Interface Science. Bd. 623 (2022) . - S. 1142-1150.
DOI: https://doi.org/10.1016/j.jcis.2022.04.158

Mazrad, Zihnil A. I. ; Lai, May ; Davis, Thomas P. ; Nicolazzo, Joseph A. ; Thurecht, Kristofer J. ; Leiske, Meike N. ; Kempe, Kristian:
Protected amine-functional initiators for the synthesis of α-amine homo- and heterotelechelic poly(2-ethyl-2-oxazoline)s.
In: Polymer Chemistry. Bd. 13 (2022) Heft 30 . - S. 4436-4445.
DOI: https://doi.org/10.1039/D2PY00649A

Leiske, Meike N. ; Mazrad, Zihnil A. I. ; Zelcak, Aykut ; Wahi, Kanu ; Davis, Thomas P. ; McCarroll, Joshua A. ; Holst, Jeff ; Kempe, Kristian:
Zwitterionic Amino Acid-Derived Polyacrylates as Smart Materials Exhibiting Cellular Specificity and Therapeutic Activity.
In: Biomacromolecules. Bd. 23 (2022) Heft 6 . - S. 2374-2387.
DOI: https://doi.org/10.1021/acs.biomac.2c00143

Deepagan, Veerasikku Gopal ; Leiske, Meike N. ; Fletcher, Nicholas L. ; Rudd, David ; Tieu, Terence ; Kirkwood, Nicholas ; Thurecht, Kristofer J. ; Kempe, Kristian ; Voelcker, Nicolas H. ; Cifuentes-Rius, Anna:
Engineering Fluorescent Gold Nanoclusters Using Xanthate-Functionalized Hydrophilic Polymers : Toward Enhanced Monodispersity and Stability.
In: Nano Letters. Bd. 21 (2021) Heft 1 . - S. 476-484.
DOI: https://doi.org/10.1021/acs.nanolett.0c03930

Leiske, Meike N. ; Lai, May ; Amarasena, Thakshila ; Davis, Thomas P. ; Thurecht, Kristofer J. ; Kent, Stephen J. ; Kempe, Kristian:
Interactions of core cross-linked poly(2-oxazoline) and poly(2-oxazine) micelles with immune cells in human blood.
In: Biomaterials. Bd. 274 (2021) . - 120843.
DOI: https://doi.org/10.1016/j.biomaterials.2021.120843

Mazrad, Zihnil A. I. ; Schelle, Baptiste ; Nicolazzo, Joseph A. ; Leiske, Meike N. ; Kempe, Kristian:
Nitrile-Functionalized Poly(2-oxazoline)s as a Versatile Platform for the Development of Polymer Therapeutics.
In: Biomacromolecules. Bd. 22 (2021) Heft 11 . - S. 4618-4632.
DOI: https://doi.org/10.1021/acs.biomac.1c00923

Leiske, Meike N. ; Mahmoud, Ayaat M. ; Warne, Nicole M. ; Goos, Jeroen A. C. M. ; Pascual, Sagrario ; Montembault, Véronique ; Fontaine, Laurent ; Davis, Thomas P. ; Whittaker, Michael R. ; Kempe, Kristian:
Poly(2-isopropenyl-2-oxazoline) : a structural analogue to poly(vinyl azlactone) with Orthogonal Reactivity.
In: Polymer Chemistry. Bd. 11 (2020) Heft 35 . - S. 5681-5692.
DOI: https://doi.org/10.1039/D0PY00861C

Leiske, Meike N. ; Walker, Julia A. ; Zia, Aadarash ; Fletcher, Nicholas L. ; Thurecht, Kristofer J. ; Davis, Thomas P. ; Kempe, Kristian:
Synthesis of biscarboxylic acid functionalised EDTA mimicking polymers and their ability to form Zr(iv) chelation mediated nanostructures.
In: Polymer Chemistry. Bd. 11 (2020) Heft 16 . - S. 2799-2810.
DOI: https://doi.org/10.1039/D0PY00304B

Trützschler, Anne-Kristin ; Leiske, Meike N. ; Strumpf, Maria ; Brendel, Johannes C. ; Schubert, Ulrich S.:
One-Pot Synthesis of Block Copolymers by a Combination of Living Cationic and Controlled Radical Polymerization.
In: Macromolecular Rapid Communications. Bd. 40 (2019) Heft 1 . - 1800398.
DOI: https://doi.org/10.1002/marc.201800398

Wei, Peng ; Gangapurwala, Gauri ; Pretzel, David ; Leiske, Meike N. ; Wang, Limin ; Hoeppener, Stephanie ; Schubert, Stephanie ; Brendel, Johannes C. ; Schubert, Ulrich S.:
Smart pH-Sensitive Nanogels for Controlled Release in an Acidic Environment.
In: Biomacromolecules. Bd. 20 (2019) Heft 1 . - S. 130-140.
DOI: https://doi.org/10.1021/acs.biomac.8b01228

Engel, Nora ; Dirauf, Michael ; Seupel, Susanne ; Leiske, Meike N. ; Schubert, Stephanie ; Schubert, Ulrich S.:
Utilization of 4-(trifluoromethyl)benzenesulfonates as Counter Ions Tunes the Initiator Efficiency of Sophisticated Initiators for the Preparation of Well-Defined poly(2-oxazoline)s.
In: Macromolecular Rapid Communications. Bd. 40 (2019) Heft 12 . - 1900094.
DOI: https://doi.org/10.1002/marc.201900094

Hertz, David ; Leiske, Meike N. ; Wloka, Thomas ; Traeger, Anja ; Hartlieb, Matthias ; Kessels, Michael M. ; Schubert, Stephanie ; Qualmann, Britta ; Schubert, Ulrich S.:
Comparison of random and gradient amino functionalized poly(2-oxazoline)s : Can the transfection efficiency be tuned by the macromolecular structure?
In: Journal of Polymer Science Part A: Polymer Chemistry. Bd. 56 (2018) Heft 12 . - S. 1210-1224.
DOI: https://doi.org/10.1002/pola.29000

Leiske, Meike N. ; Sobotta, Fabian H. ; Richter, Friederike ; Hoeppener, Stephanie ; Brendel, Johannes C. ; Traeger, Anja ; Schubert, Ulrich S.:
How To Tune the Gene Delivery and Biocompatibility of Poly(2-(4-aminobutyl)-2-oxazoline) by Self- and Coassembly.
In: Biomacromolecules. Bd. 19 (2018) Heft 3 . - S. 748-760.
DOI: https://doi.org/10.1021/acs.biomac.7b01535

Grube, Mandy ; Leiske, Meike N. ; Schubert, Ulrich S. ; Nischang, Ivo:
POx as an Alternative to PEG? A Hydrodynamic and Light Scattering Study.
In: Macromolecules. Bd. 51 (2018) Heft 5 . - S. 1905-1916.
DOI: https://doi.org/10.1021/acs.macromol.7b02665

Hoelzer, Doerte ; Leiske, Meike N. ; Hartlieb, Matthias ; Bus, Tanja ; Pretzel, David ; Hoeppener, Stephanie ; Kempe, Kristian ; Thierbach, René ; Schubert, Ulrich S.:
Tumor targeting with pH-responsive poly(2-oxazoline)-based nanogels for metronomic doxorubicin treatment.
In: Oncotarget. Bd. 9 (2018) Heft 32 . - S. 22316-22331.
DOI: https://doi.org/10.18632/oncotarget.24806

Leiske, Meike N. ; Trützschler, Anne-Kristin ; Armoneit, Sabine ; Sungur, Pelin ; Hoeppener, Stephanie ; Lehmann, Marc ; Traeger, Anja ; Schubert, Ulrich S.:
Mission ImPOxable : or the unknown utilization of non-toxic poly(2-oxazoline)s as cryoprotectants and surfactants at the same time.
In: Journal of Materials Chemistry B. Bd. 5 (2017) Heft 46 . - S. 9102-9113.
DOI: https://doi.org/10.1039/C7TB02443F

Lühmann, Tessa ; Schmidt, Marcel ; Leiske, Meike N. ; Spieler, Valerie ; Majdanski, Tobias C. ; Grube, Mandy ; Hartlieb, Matthias ; Nischang, Ivo ; Schubert, Stephanie ; Schubert, Ulrich S. ; Meinel, Lorenz:
Site-Specific POxylation of Interleukin-4.
In: ACS Biomaterials Science & Engineering. Bd. 3 (2017) Heft 3 . - S. 304-312.
DOI: https://doi.org/10.1021/acsbiomaterials.6b00578

Hartlieb, Matthias ; Bus, Tanja ; Kübel, Joachim ; Pretzel, David ; Hoeppener, Stephanie ; Leiske, Meike N. ; Kempe, Kristian ; Dietzek, Benjamin ; Schubert, Ulrich S.:
Tailoring Cellular Uptake and Fluorescence of Poly(2-oxazoline)-Based Nanogels.
In: Bioconjugate Chemistry. Bd. 28 (2017) Heft 4 . - S. 1229-1235.
DOI: https://doi.org/10.1021/acs.bioconjchem.7b00067

Leiske, Meike N. ; Hartlieb, Matthias ; Sobotta, Fabian H. ; Paulus, Renzo M. ; Görls, Helmar ; Bellstedt, Peter ; Schubert, Ulrich S.:
Cationic ring-opening polymerization of protected oxazolidine imines resulting in gradient copolymers of poly(2-oxazoline) and poly(urea).
In: Polymer Chemistry. Bd. 7 (2016) Heft 30 . - S. 4924-4936.
DOI: https://doi.org/10.1039/C6PY00785F

Leiske, Meike N. ; Hartlieb, Matthias ; Paulenz, Christian ; Pretzel, David ; Hentschel, Martin ; Englert, Christoph ; Gottschaldt, Michael ; Schubert, Ulrich S.:
Lab in a Tube : Purification, Amplification, and Detection of DNA Using Poly(2-oxazoline) Multilayers.
In: Advanced Functional Materials. Bd. 25 (2015) Heft 16 . - S. 2458-2466.
DOI: https://doi.org/10.1002/adfm.201404510