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Nerve guidance conduit design based on self-rolling tubes

Title data

Aigner, T. B. ; Haynl, Christian ; Salehi, Sahar ; O'Connor, A. ; Scheibel, Thomas:
Nerve guidance conduit design based on self-rolling tubes.
In: Materials Today Bio. Vol. 5 (2020) . - 100042.
ISSN 2590-0064

Abstract in another language

The current gold standard in peripheral nerve repair is nerve autografts for bridging gaps larger than a centimeter. However, autografts are associated with a low availability and the loss of function at the donor site. Nerve guidance conduits (NGCs) made of biocompatible and biodegradable materials reflect suitable alternatives. Clinically approved NGCs comprise either wraps that are rolled around the loose ends of the nerve or steady-state tubes; however, both lack internal guidance structures. Here, we established self-rolling NGCs to allow for gentle encapsulation of nerve cells together with supportive microenvironments, such as (1) an inner tube wall coating with a bioactive spider silk film, (2) an inner tube wall lining using an anisotropic spider silk non-woven mat, or (3) a luminal filler using an anisotropic collagen cryogel. Neuronal cells adhered and differentiated inside the modified tubes and formed neurites, which were oriented along the guidance structures provided by the spider silk non-woven mat or by the fibrillary structure of the collagen cryogel. Thus, our size-adaptable NGCs provide several features useful for peripheral nerve repair, and distinct combinations of the used elements might support and enhance the clinical outcome.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Peripheral nerve repair; Electrospinning; Layer-by-layer film; Recombinant spider silk; Collagen; Cryogel
Institutions of the University: Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences > 610 Medicine and health
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 09 Mar 2023 13:05
Last Modified: 09 Mar 2023 13:05