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Ostrovidov, Serge ; Ebrahimi, Majid ; Bae, Hojae ; Nguyen, Hung Kim ; Salehi, Sahar ; Kim, Sang Bok ; Kumatani, Akichika ; Matsue, Tomokazu ; Shi, Xuetao ; Nakajima, Ken ; Hidema, Shizu ; Osanai, Makoto ; Khademhosseini, Ali:
Gelatin–Polyaniline Composite Nanofibers Enhanced Excitation–Contraction Coupling System Maturation in Myotubes.
In: ACS Applied Materials & Interfaces.
Bd. 9
(2017)
Heft 49
.
- S. 42444-42458.
ISSN 1944-8252
DOI: https://doi.org/10.1021/acsami.7b03979
Abstract
In this study, composite gelatin–polyaniline (PANI) nanofibers doped with camphorsulfonic acid (CSA) were fabricated by electrospinning and used as substrates to culture C2C12 myoblast cells. We observed enhanced myotube formation on composite gelatin–PANI nanofibers compared to gelatin nanofibers, concomitantly with enhanced myotube maturation. Thus, in myotubes, intracellular organization, colocalization of the dihydropyridine receptor (DHPR) and ryanodine receptor (RyR), expression of genes correlated to the excitation–contraction (E–C) coupling apparatus, calcium transients, and myotube contractibility were increased. Such composite material scaffolds combining topographical and electrically conductive cues may be useful to direct skeletal muscle cell organization and to improve cellular maturation, functionality, and tissue formation.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Keywords: | composite nanofibers; polyaniline; gelatin; excitation−contraction coupling; myotube maturation; intracellular calcium; C2C12 |
| Institutionen der Universität: | Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Biomaterialien |
| Titel an der UBT entstanden: | Ja |
| Themengebiete aus DDC: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit 600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften |
| Eingestellt am: | 10 Mär 2023 07:59 |
| Letzte Änderung: | 10 Mär 2023 07:59 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/74172 |