bei Google ScholarTitelangaben
Ostrovidov, Serge ; Shi, Xuetao ; Sadeghian, Ramin Banan ; Salehi, Sahar ; Fujie, Toshinori ; Bae, Hojae ; Ramalingam, Murugan ; Khademhosseini, Ali:
Stem Cell Differentiation Toward the Myogenic Lineage for Muscle Tissue Regeneration : A Focus on Muscular Dystrophy.
In: Stem Cell Reviews and Reports.
Bd. 11
(2015)
Heft 6
.
- S. 866-884.
ISSN 2629-3277
DOI: https://doi.org/10.1007/s12015-015-9618-4
Abstract
Skeletal muscle tissue engineering is one of the important ways for regenerating functionally defective muscles. Among the myopathies, the Duchenne muscular dystrophy (DMD) is a progressive disease due to mutations of the dystrophin gene leading to progressive myofiber degeneration with severe symptoms. Although current therapies in muscular dystrophy are still very challenging, important progress has been made in materials science and in cellular technologies with the use of stem cells. It is therefore useful to review these advances and the results obtained in a clinical point of view. This article focuses on the differentiation of stem cells into myoblasts, and their application in muscular dystrophy. After an overview of the different stem cells that can be induced to differentiate into the myogenic lineage, we introduce scaffolding materials used for muscular tissue engineering. We then described some widely used methods to differentiate different types of stem cell into myoblasts. We highlight recent insights obtained in therapies for muscular dystrophy. Finally, we conclude with a discussion on stem cell technology. We discussed in parallel the benefits brought by the evolution of the materials and by the expansion of cell sources which can differentiate into myoblasts. We also discussed on future challenges for clinical applications and how to accelerate the translation from the research to the clinic in the frame of DMD.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Biomaterialien |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit 600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften |
| Eingestellt am: | 10 Mär 2023 10:56 |
| Letzte Änderung: | 10 Mär 2023 10:56 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/74183 |