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Measuring Nuclear Mechanics with Atomic Force Microscopy

Title data

dos Santos, Ália ; Rehfeldt, Florian ; Toseland, Christopher P.:
Measuring Nuclear Mechanics with Atomic Force Microscopy.
In: Leake, Mark C. (ed.): Chromosome Architecture : Methods and Protocols. - New York : Humana Press , 2022 . - pp. 171-181
ISBN 978-1-0716-2221-6

Official URL: Volltext

Abstract in another language

Atomic force microscopy is an ideal tool to map topography and mechanical properties of materials on the micro- and nanoscale. Here, we describe its application to measure and analyze the mechanics, in particular the effective Young's elastic modulus E* of the mammalian nucleus in live cells. We present three approaches which enable the mechanics to be probed under varying conditions. This includes fully adhered cells, initially adhered cells which lack an established cytoskeleton, and purified nuclei to study their isolated response.

Further data

Item Type: Article in a book
Refereed: Yes
Institutions of the University: Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Chair Experimental Physics I - Physics of Living Matter > Chair Experimental Physics I - Physics of Living Matter - Univ.-Prof. Dr. Matthias Weiss
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 530 Physics
500 Science > 570 Life sciences, biology
Date Deposited: 17 Mar 2023 07:50
Last Modified: 17 Mar 2023 07:50