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Bocklitz, Thomas ; Crecelius, Anna C. ; Matthäus, Christian ; Tarcea, Nicolae ; von Eggeling, Ferdinand ; Schmitt, Michael ; Schubert, Ulrich S. ; Popp, Jürgen:
Deeper understanding of biological tissue : Quantitative correlation of MALDI-TOF and Raman imaging.
In: Analytical Chemistry.
Bd. 85
(2013)
Heft 22
.
- S. 10829-10834.
ISSN 1520-6882
DOI: https://doi.org/10.1021/ac402175c
Abstract
In order to achieve a comprehensive description of biological tissue, spectral information about proteins, lipids, nucleic acids, and other biochemical components need to be obtained concurrently. Different analytical techniques may be combined to record complementary information of the same sample. Established techniques, which can be utilized to elucidate the biochemistry of tissue samples are, for instance, MALDI-TOF-MS and Raman microscopic imaging. With this contribution, we combine these two techniques for the first time. The combination of both techniques allows the utilization and interpretation of complementary information (i.e., the information about the protein composition derived from the Raman spectra with data of the lipids analyzed by the MALDI-TOF measurements). Furthermore, we demonstrate how spectral information from MALDI-TOF experiments can be utilized to interpret Raman spectra.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Mathematik, Physik und Informatik > Institut für Informatik > Lehrstuhl Künstliche Intelligenz in der Mikroskopie und Spektroskopie > Lehrstuhl Künstliche Intelligenz in der Mikroskopie und Spektroskopie - Univ.-Prof. Dr. Thomas Wilhelm Bocklitz |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 530 Physik |
| Eingestellt am: | 19 Mai 2023 10:19 |
| Letzte Änderung: | 19 Mai 2023 10:19 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/76291 |