Raman Spectroscopy to Characterize Bladder Tissue for Multidimensional Diagnostics of Cancer in Urology

Titelangaben

Krafft, Christoph ; Guo, Shuxia ; Bocklitz, Thomas ; Bronsert, Peter ; Miernik, Arkadiusz ; Popp, Jürgen:
Raman Spectroscopy to Characterize Bladder Tissue for Multidimensional Diagnostics of Cancer in Urology.
In: Current Directions in Biomedical Engineering. Bd. 6 (2020) Heft 3 . - S. 250-253.
ISSN 2364-5504
DOI: https://doi.org/10.1515/cdbme-2020-3063

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Abstract

Fiber optic Raman spectroscopy offers label-free identification of cancer in the bladder under in vivo conditions. However, state-of-the-art Raman technology does not enable to scan the entire bladder wall. Our multidimensional approach within the project Uro-MDD combines panoramic 3D-image reconstruction of white light cystoscopy and fluorescence lifetime imaging to define regions of interest for Raman-assisted diagnos-tics. First Raman results are presented from human control and cancer bladder specimens that demonstrat-ed how to obtain specific molecular information. Such Raman images can be used in a clinical setting to de-termine cancer margins and the resection status. Fiber probes are under development to translate the tech-nique to in vivo screening.