at Google ScholarTitle data
Zimmermann, Paul ; Aberer, Felix ; Eckstein, Max L. ; Haupt, Sandra ; Erlmann, Maximilian P. ; Moser, Othmar:
Verapamil and Its Role in Diabetes.
In: Diabetology.
Vol. 3
(2022)
Issue 3
.
- pp. 393-406.
ISSN 2673-4540
DOI: https://doi.org/10.3390/diabetology3030030
Abstract in another language
Autoimmune pancreatic β-cell loss and destruction play a key role in the pathogenesis and development of type 1 diabetes, with a prospective increased risk for developing micro- and macrovascular complications. In this regard, orally administrated verapamil, a calcium channel antagonist, usually intended for use as an anti-arrhythmic drug, has previously shown potential beneficial effects on β-cell preservation in new-onset type 1 diabetes. Furthermore, observational data suggest a reduced risk of type 2 diabetes development. The underlying pathophysiological mechanisms are not well investigated and remain widely inconclusive. The aim of this narrative review was to detail the role of verapamil in promoting endogenous β-cell function, potentially eligible for early treatment in type 1 diabetes, and to summarize existing evidence on its effect on glycemia in individuals with type 2 diabetes.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Cultural Studies > Department of Sport Science > Chair Exercise Physiology > Chair Exercise Physiology - Univ.-Prof. Dr. Othmar Moser Faculties > Faculty of Cultural Studies > Department of Sport Science > Professor Sport Science IV - Sports Medicine and Sports Physiology Faculties Faculties > Faculty of Cultural Studies Faculties > Faculty of Cultural Studies > Department of Sport Science Faculties > Faculty of Cultural Studies > Department of Sport Science > Chair Exercise Physiology |
| Result of work at the UBT: | Yes |
| DDC Subjects: | 600 Technology, medicine, applied sciences > 610 Medicine and health |
| Date Deposited: | 30 May 2023 08:21 |
| Last Modified: | 12 Jul 2023 13:38 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/76588 |