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Cellular chemomechanics at interfaces : sensing, integration and response

Title data

Girard, Philippe P. ; Cavalcanti-Adam, Elisabetta Ada ; Kemkemer, Ralf ; Spatz, Joachim P.:
Cellular chemomechanics at interfaces : sensing, integration and response.
In: Soft Matter. Vol. 3 (2007) Issue 3 . - pp. 307-326.
ISSN 1744-6848

Abstract in another language

Living cells are complex entities whose remarkable, emergent capacity to sense, integrate, and respond to environmental cues relies on an intricate series of interactions among the cell's macromolecular components. Defects in mechanosensing, transduction,or responses underlie many diseases such as cancers, immune disorders, cardiac hypertrophy, genetic malformations, and neuropathies. Here, we highlight micro- and nanotechnology-based tools that have been used to study how chemical and mechanical cues modulate the responses of single cells in contact with the extracellular environment. Understanding the physical aspects of these complex processes at the micro- and nanometer scale could produce profound and fundamental new insights into how the processes of cell migration, metastasis, immune function and other areas which are regulated by mechanical forces.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics > Chair Cellular Biomechanics - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam
Result of work at the UBT: No
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 12 Jun 2023 13:53
Last Modified: 12 Jun 2023 13:53