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Selective modulation of cell response on engineered fractal silicon substrates

Title data

Gentile, Francesco ; Medda, Rebecca ; Cheng, Ling ; Battista, Edmondo ; Scopelliti, Pasquale E. ; Milani, Paolo ; Cavalcanti-Adam, Elisabetta Ada ; Decuzzi, Paolo:
Selective modulation of cell response on engineered fractal silicon substrates.
In: Scientific Reports. Vol. 3 (2013) Issue 1 . - 1461.
ISSN 2045-2322

Abstract in another language

A plethora of work has been dedicated to the analysis of cell behavior on substrates with ordered topographical features. However, the natural cell microenvironment is characterized by biomechanical cues organized over multiple scales. Here, randomly rough, self-affinefractal surfaces are generated out of silicon,where roughness Ra and fractal dimension Df are independently controlled. The proliferation rates, the formation of adhesion structures and the morphology of 3T3 murine fibroblasts are monitored over six different substrates. The proliferation rate is maximized on surfaces with moderate roughness (Ra ~ 40 nm) and large fractal dimension (Df ~ 2.4); whereas adhesion structures are wider and more stable on substrates with higher roughness (Ra ~ 50 nm) and lower fractal dimension (Df ~ 2.2). Higher proliferation occurson substrates exhibiting densely packed and sharp peaks, whereas more regular ridges favor adhesion. These results suggest that randomly roughtopographies can selectively modulate cell behavior.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics > Chair Cellular Biomechanics - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam
Result of work at the UBT: No
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 12 Jun 2023 13:15
Last Modified: 12 Jun 2023 13:15