at Google ScholarTitle data
de Beer, Alex G. F. ; Cavalcanti-Adam, Elisabetta Ada ; Majer, Günter ; Lopez-García, M. ; Kessler, H. ; Spatz, Joachim P.:
Force-induced destabilization of focal adhesions at defined integrin spacings on nanostructured surfaces.
In: Physical Review E.
Vol. 81
(2010)
Issue 5
.
- 051914.
ISSN 1550-2376
DOI: https://doi.org/10.1103/PhysRevE.81.051914
Abstract in another language
Focal adhesions are the anchoring points of cells to surfaces and are responsible for a large number of surface sensing processes. Nanopatterning studies have shown physiological changes in fibroblasts as a result of decreasing density of external binding ligands. The most striking of these changes is a decreased ability to form mature focal adhesions when lateral ligand distances exceed 76 nm. These changes are usually examined in the context of protein signaling and protein interactions. We show a physical explanation based on the balance between the forces acting on individual ligand connections and the reaction kinetics of those ligands. We propose three stability regimes for focal adhesions as a function of ligand spacing and applied stress: a stable regime, an unstable regime in which a large fraction of unbound protein causes adhesion disintegration, and a regime in which the applied force is too high to form an adhesion structure.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics > Chair Cellular Biomechanics - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam Faculties Faculties > Faculty of Engineering Science Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics |
| Result of work at the UBT: | No |
| DDC Subjects: | 600 Technology, medicine, applied sciences > 620 Engineering |
| Date Deposited: | 12 Jun 2023 12:57 |
| Last Modified: | 29 Nov 2023 07:57 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/81169 |