at Google ScholarTitle data
Schwab, Elisabeth H. ; Pohl, Theresa L. M. ; Haraszti, Tamás ; Schwaerzer, Gerburg K. ; Hiepen, Christian ; Spatz, Joachim P. ; Knaus, Petra ; Cavalcanti-Adam, Elisabetta Ada:
Nanoscale control of surface immobilized BMP-2 : toward a quantitative assessment of BMP-mediated signaling events.
In: Nano Letters.
Vol. 15
(2015)
Issue 3
.
- pp. 1526-1534.
ISSN 1530-6992
DOI: https://doi.org/10.1021/acs.nanolett.5b00315
Abstract in another language
In this work we determine the impact of surface density of immobilized BMP-2 on intracellular signal transduction. We use block copolymer micellar nanolithography to fabricate substrates with precisely spaced and tunable gold nanoparticle arrays carrying single BMP-2 molecules. We found that the immobilized growth factor triggers prolonged and elevated Smad signaling pathway activation compared to the same amount of soluble protein. This approach is suitable for achieving controlled and sustained local delivery of BMP-2 and other growth factors.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Keywords: | BCMN; gold nanostructures; BMP-2; covalent immobilization; cell signaling |
| Institutions of the University: | Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics > Chair Cellular Biomechanics - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam |
| Result of work at the UBT: | No |
| DDC Subjects: | 600 Technology, medicine, applied sciences > 620 Engineering |
| Date Deposited: | 12 Jun 2023 12:11 |
| Last Modified: | 12 Jun 2023 12:11 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/81175 |