at Google ScholarTitle data
Wei, Qiang ; Pohl, Theresa L. M. ; Seckinger, Anja ; Spatz, Joachim P. ; Cavalcanti-Adam, Elisabetta Ada:
Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation.
In: Beilstein Journal of Organic Chemistry.
Vol. 11
(2015)
Issue 1
.
- pp. 773-783.
ISSN 1860-5397
DOI: https://doi.org/10.3762/bjoc.11.87
Abstract in another language
Stem cells respond to the microenvironment (niche) they are located in. Under natural conditions, the extracellular matrix (ECM) is the essential component the in stem cell niche, in which both integrin ligands and growth factors are important regulators to directly or indirectly modulate the cell behavior. In this review, we summarize the current knowledge about the potential of integrin ligands and growth factors to induce osteogenic differentiation of stem cells, and discuss the signaling pathways that are initiated by both individual and cooperative parameters. The joint effect of integrin ligands and growth factors is highlighted as the multivalent interactions for bone therapy.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Keywords: | biomaterials; growth factor; integrin; osteodifferentiation; stem cells |
| Institutions of the University: | Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics > Chair Cellular Biomechanics - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam |
| Result of work at the UBT: | No |
| DDC Subjects: | 600 Technology, medicine, applied sciences > 620 Engineering |
| Date Deposited: | 12 Jun 2023 11:55 |
| Last Modified: | 12 Jun 2023 11:55 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/81176 |