bei Google ScholarTitelangaben
Wei, Qiang ; Pohl, Theresa L. M. ; Seckinger, Anja ; Spatz, Joachim P. ; Cavalcanti-Adam, Elisabetta Ada:
Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation.
In: Beilstein Journal of Organic Chemistry.
Bd. 11
(2015)
Heft 1
.
- S. 773-783.
ISSN 1860-5397
DOI: https://doi.org/10.3762/bjoc.11.87
Abstract
Stem cells respond to the microenvironment (niche) they are located in. Under natural conditions, the extracellular matrix (ECM) is the essential component the in stem cell niche, in which both integrin ligands and growth factors are important regulators to directly or indirectly modulate the cell behavior. In this review, we summarize the current knowledge about the potential of integrin ligands and growth factors to induce osteogenic differentiation of stem cells, and discuss the signaling pathways that are initiated by both individual and cooperative parameters. The joint effect of integrin ligands and growth factors is highlighted as the multivalent interactions for bone therapy.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Keywords: | biomaterials; growth factor; integrin; osteodifferentiation; stem cells |
| Institutionen der Universität: | Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Zelluläre Biomechanik > Lehrstuhl Zelluläre Biomechanik - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften |
| Eingestellt am: | 12 Jun 2023 11:55 |
| Letzte Änderung: | 12 Jun 2023 11:55 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/81176 |